Literature DB >> 14504248

The extent of linkage disequilibrium and haplotype sharing around a polymorphic site.

Hideki Innan1, Magnus Nordborg.   

Abstract

Various expressions related to the length of a conserved haplotype around a polymorphism of known frequency are derived. We obtain exact expressions for the probability that no recombination has occurred in a sample or subsample. We obtain an approximation for the probability that no recombination that could give rise to a detectable recombination event (through the four-gamete test) has occurred. The probabilities can be used to obtain approximate distributions for the length of variously defined haplotypes around a polymorphic site. The implications of our results for data analysis, and in particular for detecting selection, are discussed.

Mesh：

Year:  2003        PMID： 14504248      PMCID： PMC1462757     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  24 in total

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Review 3.  Linkage disequilibrium: what history has to tell us.

Authors:  Magnus Nordborg; Simon Tavaré
Journal:  Trends Genet       Date:  2002-02       Impact factor: 11.639

4.  The use of intraallelic variability for testing neutrality and estimating population growth rate.

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Journal:  Genetics       Date:  2001-06       Impact factor: 4.562

5.  The structure of haplotype blocks in the human genome.

Authors:  Stacey B Gabriel; Stephen F Schaffner; Huy Nguyen; Jamie M Moore; Jessica Roy; Brendan Blumenstiel; John Higgins; Matthew DeFelice; Amy Lochner; Maura Faggart; Shau Neen Liu-Cordero; Charles Rotimi; Adebowale Adeyemo; Richard Cooper; Ryk Ward; Eric S Lander; Mark J Daly; David Altshuler
Journal:  Science       Date:  2002-05-23       Impact factor: 47.728

6.  Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots.

Authors:  M S Phillips; R Lawrence; R Sachidanandam; A P Morris; D J Balding; M A Donaldson; J F Studebaker; W M Ankener; S V Alfisi; F-S Kuo; A L Camisa; V Pazorov; K E Scott; B J Carey; J Faith; G Katari; H A Bhatti; J M Cyr; V Derohannessian; C Elosua; A M Forman; N M Grecco; C R Hock; J M Kuebler; J A Lathrop; M A Mockler; E P Nachtman; S L Restine; S A Varde; M J Hozza; C A Gelfand; J Broxholme; G R Abecasis; M T Boyce-Jacino; L R Cardon
Journal:  Nat Genet       Date:  2003-02-18       Impact factor: 38.330

7.  The pattern of polymorphism on human chromosome 21.

Authors:  Hideki Innan; Badri Padhukasahasram; Magnus Nordborg
Journal:  Genome Res       Date:  2003-06       Impact factor: 9.043

8.  The amounts of nucleotide variation within and between allelic classes and the reconstruction of the common ancestral sequence in a population.

Authors:  H Innan; F Tajima
Journal:  Genetics       Date:  1997-11       Impact factor: 4.562

9.  Evolutionary relationship of DNA sequences in finite populations.

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Journal:  Genetics       Date:  1983-10       Impact factor: 4.562

10.  Statistical properties of the number of recombination events in the history of a sample of DNA sequences.

Authors:  R R Hudson; N L Kaplan
Journal:  Genetics       Date:  1985-09       Impact factor: 4.562
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  11 in total

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Authors:  Erica G Bakker; M Brian Traw; Christopher Toomajian; Martin Kreitman; Joy Bergelson
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Journal:  Genetics       Date:  2006-04-02       Impact factor: 4.562

7.  Microevolutionary dynamics of a macroevolutionary key innovation in a Lepidopteran herbivore.

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9.  Studying models of balancing selection using phase-type theory.

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10.  A nonparametric test reveals selection for rapid flowering in the Arabidopsis genome.

Authors:  Christopher Toomajian; Tina T Hu; Maria José Aranzana; Clare Lister; Chunlao Tang; Honggang Zheng; Keyan Zhao; Peter Calabrese; Caroline Dean; Magnus Nordborg
Journal:  PLoS Biol       Date:  2006-04-25       Impact factor: 8.029
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