| Literature DB >> 12590262 |
M S Phillips1, R Lawrence, R Sachidanandam, A P Morris, D J Balding, M A Donaldson, J F Studebaker, W M Ankener, S V Alfisi, F-S Kuo, A L Camisa, V Pazorov, K E Scott, B J Carey, J Faith, G Katari, H A Bhatti, J M Cyr, V Derohannessian, C Elosua, A M Forman, N M Grecco, C R Hock, J M Kuebler, J A Lathrop, M A Mockler, E P Nachtman, S L Restine, S A Varde, M J Hozza, C A Gelfand, J Broxholme, G R Abecasis, M T Boyce-Jacino, L R Cardon.
Abstract
Recent studies of human populations suggest that the genome consists of chromosome segments that are ancestrally conserved ('haplotype blocks'; refs. 1-3) and have discrete boundaries defined by recombination hot spots. Using publicly available genetic markers, we have constructed a first-generation haplotype map of chromosome 19. As expected for this marker density, approximately one-third of the chromosome is encompassed within haplotype blocks. Evolutionary modeling of the data indicates that recombination hot spots are not required to explain most of the observed blocks, providing that marker ascertainment and the observed marker spacing are considered. In contrast, several long blocks are inconsistent with our evolutionary models, and different mechanisms could explain their origins.Entities:
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Year: 2003 PMID： 12590262 DOI： 10.1038/ng1100
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330