BACKGROUND: There is suggestive evidence that residential radon increases lung cancer risk. To elucidate this association further, we conducted a case-control study in Thuringia and Saxony in Eastern Germany during 1990-1997. METHODS: Histologically confirmed lung cancer patients from hospitals and a random sample of population controls matched on age, sex and geographical area were personally interviewed with respect to residential history, smoking, and other risk factors. One-year radon measurements were performed in houses occupied during the 5-35 years prior to the interview. The final analysis included a total of 1,192 cases and 1,640 controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression. RESULTS: Measurements covered on average 72% of the exposure time window, with mean radon concentrations of 76 Bq/m3 among the cases and 74 Bq/m3 among the controls. The smoking- and asbestos-adjusted ORs for categories of radon (50-80, 80-140 and >140 Bq/m*3, compared with 0-50 Bq/m3) were 0.95 (CI = 0.77 to 1.18), 1.13 (CI = 0.86 to1.50) and 1.30 (CI = 0.88 to 1.93). The excess relative risk per 100 Bq/mł was 0.08 (CI = -0.03 to 0.20) for all subjects and 0.09 (CI = -0.06 to 0.27) for subjects with complete measurements for all 30 years. CONCLUSIONS: Our data indicate a small increase in lung cancer risk as a result of residential radon that is consistent with the findings of previous indoor radon and miner studies.
BACKGROUND: There is suggestive evidence that residential radon increases lung cancer risk. To elucidate this association further, we conducted a case-control study in Thuringia and Saxony in Eastern Germany during 1990-1997. METHODS: Histologically confirmed lung cancerpatients from hospitals and a random sample of population controls matched on age, sex and geographical area were personally interviewed with respect to residential history, smoking, and other risk factors. One-year radon measurements were performed in houses occupied during the 5-35 years prior to the interview. The final analysis included a total of 1,192 cases and 1,640 controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression. RESULTS: Measurements covered on average 72% of the exposure time window, with mean radon concentrations of 76 Bq/m3 among the cases and 74 Bq/m3 among the controls. The smoking- and asbestos-adjusted ORs for categories of radon (50-80, 80-140 and >140 Bq/m*3, compared with 0-50 Bq/m3) were 0.95 (CI = 0.77 to 1.18), 1.13 (CI = 0.86 to1.50) and 1.30 (CI = 0.88 to 1.93). The excess relative risk per 100 Bq/mł was 0.08 (CI = -0.03 to 0.20) for all subjects and 0.09 (CI = -0.06 to 0.27) for subjects with complete measurements for all 30 years. CONCLUSIONS: Our data indicate a small increase in lung cancer risk as a result of residential radon that is consistent with the findings of previous indoor radon and miner studies.
Authors: Albert Rosenberger; Heike Bickeböller; Valerie McCormack; Darren R Brenner; Eric J Duell; Anne Tjønneland; Soren Friis; Joshua E Muscat; Ping Yang; H-Erich Wichmann; Joachim Heinrich; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; David Zaridze; Peter Rudnai; Eleonora Fabianova; Vladimir Janout; Vladimir Bencko; Paul Brennan; Dana Mates; Ann G Schwartz; Michele L Cote; Zuo-Feng Zhang; Hal Morgenstern; Sam S Oh; John K Field; Olaide Raji; John R McLaughlin; John Wiencke; Loic LeMarchand; Monica Neri; Stefano Bonassi; Angeline S Andrew; Qing Lan; Wei Hu; Irene Orlow; Bernard J Park; Paolo Boffetta; Rayjean J Hung Journal: Carcinogenesis Date: 2011-12-22 Impact factor: 4.944
Authors: Darren R Brenner; Paolo Boffetta; Eric J Duell; Heike Bickeböller; Albert Rosenberger; Valerie McCormack; Joshua E Muscat; Ping Yang; H-Erich Wichmann; Irene Brueske-Hohlfeld; Ann G Schwartz; Michele L Cote; Anne Tjønneland; Søren Friis; Loic Le Marchand; Zuo-Feng Zhang; Hal Morgenstern; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; David Zaridze; Peter Rudnai; Eleonora Fabianova; Lenka Foretova; Vladimir Janout; Vladimir Bencko; Miriam Schejbalova; Paul Brennan; Ioan N Mates; Philip Lazarus; John K Field; Olaide Raji; John R McLaughlin; Geoffrey Liu; John Wiencke; Monica Neri; Donatella Ugolini; Angeline S Andrew; Qing Lan; Wei Hu; Irene Orlow; Bernard J Park; Rayjean J Hung Journal: Am J Epidemiol Date: 2012-09-17 Impact factor: 4.897
Authors: Teresa Chahine; Bradley D Schultz; Valerie G Zartarian; Jianping Xue; S V Subramanian; Jonathan I Levy Journal: Int J Environ Res Public Health Date: 2011-09-13 Impact factor: 3.390
Authors: A Crispo; P Brennan; K-H Jöckel; A Schaffrath-Rosario; H-E Wichmann; F Nyberg; L Simonato; F Merletti; F Forastiere; P Boffetta; S Darby Journal: Br J Cancer Date: 2004-10-04 Impact factor: 7.640