Literature DB >> 14404586

On the mechanism of action of chlorpromazine.

G KARREMAN, I ISENBERG, A SZENT-GYORGYI.   

Abstract

Chlorpromazine is shown to be a powerful electron donor. Observations are described supporting the assumption that the therapeutic action of this drug is connected with this property.

Entities:  

Keywords:  CHLORPROMAZINE/pharmacology; OXIDATION-REDUCTION

Mesh：

Substances：

Year:  1959        PMID： 14404586     DOI： 10.1126/science.130.3383.1191

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  14 in total

1.  Uveal pigment and phenothiazine compounds.

Authors:  A M POTTS
Journal:  Trans Am Ophthalmol Soc       Date:  1962

2.  Interaction of trace metals with phenothiazine drug derivatives. III. Theoretical part.

Authors:  D C BORG; G C COTZIAS
Journal:  Proc Natl Acad Sci U S A       Date:  1962-04-15       Impact factor: 11.205

3.  Effect of nutritional deficiencies on synthesis of the inducible malic enzyme of Lactobacillus plantarum.

Authors:  H A NATHAN
Journal:  Arch Mikrobiol       Date:  1961

4.  FEATURES OF THE ELECTRONIC STRUCTURE OF THE IRON-PORPHYRIN COMPLEXES WITH SPECIAL REFERENCE TO THE OXIDO-REDUCTIVE PROPERTIES OF CYTOCHROMES.

Authors:  B Pullman; C Spanjaard; G Berthier
Journal:  Proc Natl Acad Sci U S A       Date:  1960-08       Impact factor: 11.205

5.  QUANTUM CHEMICAL STUDIES OF CHARGE-TRANSFER COMPLEXES OF INDOLES.

Authors:  J P Green; J P Malrieu
Journal:  Proc Natl Acad Sci U S A       Date:  1965-09       Impact factor: 11.205

Review 6.  Electron-transfer and charge-transfer clastic binding hypotheses for drug-receptor interactions.

Authors:  V M Kolb
Journal:  Pharm Res       Date:  1987-12       Impact factor: 4.200

7.  On the conformations of hallucinogenic molecules and their correlation.

Authors:  C Chothia; P Pauling
Journal:  Proc Natl Acad Sci U S A       Date:  1969-08       Impact factor: 11.205

8.  Comparative study on the inhibition of Na + , K + -activated ATPase activity by chlorpromazine, promazine, imipramine, and their monodesmethyl metabolites.

Authors:  H Hackenberg; J Krieglstein
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

9.  Amphetamines: correlation of activity with stability of molecular complexes.

Authors:  M T Sung; J A Parker
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

10.  A relationship between the hallucinogenic activity of drugs and their electronic configuration.

Authors:  S H Snyder; C R Merril
Journal:  Proc Natl Acad Sci U S A       Date:  1965-07       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.