Literature DB >> 4311249

On the conformations of hallucinogenic molecules and their correlation.

C Chothia, P Pauling.   

Abstract

There are only a few possible conformations of D-lysergic acid diethylamide and hallucinogenic derivatives of tryptamine and phenylethylamine. Of these possible conformations there is a high structural correlation among the probable conformations of active hallucinogenic molecules and between these conformations and the known conformations of several central nervous system transmitter molecules.

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Year:  1969        PMID： 4311249      PMCID： PMC223427          DOI： 10.1073/pnas.63.4.1063

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Cross tolerance between LSD and psilocybin.

Authors:  H ISBELL; A B WOLBACH; A WIKLER; E J MINER
Journal:  Psychopharmacologia       Date:  1961

2.  On relationships between structure and nicotine-like stimulant activity in choline esters and ethers.

Authors:  P HEY
Journal:  Br J Pharmacol Chemother       Date:  1952-03

3.  An action of 5-hydroxytryptamine on the frog motor end-plate.

Authors:  F Colomo; R Rahamimoff; E Stefani
Journal:  Eur J Pharmacol       Date:  1968-06       Impact factor: 4.432

4.  Conformations of acetylcholine.

Authors:  C Chothia; P Pauling
Journal:  Nature       Date:  1968-09-14       Impact factor: 49.962

5.  The structure of the catecholamines. I. The crystal structure of noradrenaline hydrochloride.

Authors:  D Carlström; R Bergin
Journal:  Acta Crystallogr       Date:  1967-08-10

6.  Psychedelic drugs: steric factors that predict psychotropic activity.

Authors:  S H Snyder; E Richelson
Journal:  Proc Natl Acad Sci U S A       Date:  1968-05       Impact factor: 11.205

7.  A relationship between the hallucinogenic activity of drugs and their electronic configuration.

Authors:  S H Snyder; C R Merril
Journal:  Proc Natl Acad Sci U S A       Date:  1965-07       Impact factor: 11.205

8.  The crystal and molecular structure of the serotonin-creatinine sulphate complex.

Authors:  I L Karle; K S Dragonette; S A Brenner
Journal:  Acta Crystallogr       Date:  1965-11-10

9.  Structure of acetylcholine and other substrates of cholinergic systems.

Authors:  F G Canepa; P Pauling; H Sörum
Journal:  Nature       Date:  1966-05-28       Impact factor: 49.962

10.  The crystal structures of L-tryptophan hydrochloride and hydrobromide.

Authors:  T Takigawa; T Ashida; Y Sasada; M Kakudo
Journal:  Bull Chem Soc Jpn       Date:  1966-11       Impact factor: 5.488
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  4 in total

1.  The nature of the binding between LSD and a 5-HT receptor: a possible explanation for hallucinogenic activity.

Authors:  M J Berridge; W T Prince
Journal:  Br J Pharmacol       Date:  1974-06       Impact factor: 8.739

2.  Steric and electronic relationships among some hallucinogenic compounds.

Authors:  S Kang; J P Green
Journal:  Proc Natl Acad Sci U S A       Date:  1970-09       Impact factor: 11.205

3.  Specificity of the antibody receptor site to D-lysergamide: model of a physiological receptor for lysergic acid diethylamide.

Authors:  H Van Vunakis; J T Farrow; H B Gjika; L Levine
Journal:  Proc Natl Acad Sci U S A       Date:  1971-07       Impact factor: 11.205

4.  The discriminative stimulus properties of 2,5-dimethoxy-4-methylamphetamine (DOM): differentiation from amphetamine.

Authors:  P B Silverman; B T Ho
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530
  4 in total

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