Literature DB >> 11413161

TGF-beta is a critical mediator of acute lung injury.

J F Pittet1, M J Griffiths, T Geiser, N Kaminski, S L Dalton, X Huang, L A Brown, P J Gotwals, V E Koteliansky, M A Matthay, D Sheppard.   

Abstract

We have shown that the integrin alphavbeta6 activates latent TGF-beta in the lungs and skin. We show here that mice lacking this integrin are completely protected from pulmonary edema in a model of bleomycin-induced acute lung injury (ALI). Pharmacologic inhibition of TGF-beta also protected wild-type mice from pulmonary edema induced by bleomycin or Escherichia coli endotoxin. TGF-beta directly increased alveolar epithelial permeability in vitro by a mechanism that involved depletion of intracellular glutathione. These data suggest that integrin-mediated local activation of TGF-beta is critical to the development of pulmonary edema in ALI and that blocking TGF-beta or its activation could be effective treatments for this currently untreatable disorder.

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Year:  2001        PMID： 11413161      PMCID： PMC200192          DOI： 10.1172/JCI11963

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  29 in total

1.  Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters.

Authors:  Q Wang; Y Wang; D M Hyde; P J Gotwals; V E Koteliansky; S T Ryan; S N Giri
Journal:  Thorax       Date:  1999-09       Impact factor: 9.139

Review 2.  The acute respiratory distress syndrome.

Authors:  L B Ware; M A Matthay
Journal:  N Engl J Med       Date:  2000-05-04       Impact factor: 91.245

3.  Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis.

Authors:  N Kaminski; J D Allard; J F Pittet; F Zuo; M J Griffiths; D Morris; X Huang; D Sheppard; R A Heller
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-15       Impact factor: 11.205

4.  Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance.

Authors:  A N Chesnutt; M A Matthay; F A Tibayan; J G Clark
Journal:  Am J Respir Crit Care Med       Date:  1997-09       Impact factor: 21.405

5.  Transforming growth factor-beta1 is a potent inhibitor of glutathione synthesis in the lung epithelial cell line A549: transcriptional effect on the GSH rate-limiting enzyme gamma-glutamylcysteine synthetase.

Authors:  K Arsalane; C M Dubois; T Muanza; R Bégin; F Boudreau; C Asselin; A M Cantin
Journal:  Am J Respir Cell Mol Biol       Date:  1997-11       Impact factor: 6.914

6.  Inhibition of beta-adrenergic-dependent alveolar epithelial clearance by oxidant mechanisms after hemorrhagic shock.

Authors:  K Modelska; M A Matthay; L A Brown; E Deutch; L N Lu; J F Pittet
Journal:  Am J Physiol       Date:  1999-05

7.  Rearrangement of adherens junctions by transforming growth factor-beta1: role of contraction.

Authors:  I V Hurst V; P L Goldberg; F L Minnear; R L Heimark; P A Vincent
Journal:  Am J Physiol       Date:  1999-04

8.  Ethanol ingestion via glutathione depletion impairs alveolar epithelial barrier function in rats.

Authors:  D M Guidot; K Modelska; M Lois; L Jain; I M Moss; J F Pittet; L A Brown
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2000-07       Impact factor: 5.464

9.  Soluble transforming growth factor-beta type II receptor inhibits negative remodeling, fibroblast transdifferentiation, and intimal lesion formation but not endothelial growth.

Authors:  J D Smith; S R Bryant; L L Couper; C P Vary; P J Gotwals; V E Koteliansky; V Lindner
Journal:  Circ Res       Date:  1999-05-28       Impact factor: 17.367

10.  The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.

Authors:  J S Munger; X Huang; H Kawakatsu; M J Griffiths; S L Dalton; J Wu; J F Pittet; N Kaminski; C Garat; M A Matthay; D B Rifkin; D Sheppard
Journal:  Cell       Date:  1999-02-05       Impact factor: 41.582
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  183 in total

1.  Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation.

Authors:  Mai-Lan N Huynh; Valerie A Fadok; Peter M Henson
Journal:  J Clin Invest       Date:  2002-01       Impact factor: 14.808

Review 2.  Disorders of lung matrix remodeling.

Authors:  Harold A Chapman
Journal:  J Clin Invest       Date:  2004-01       Impact factor: 14.808

3.  Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force.

Authors:  Marilyn M Giacomini; Mark A Travis; Makoto Kudo; Dean Sheppard
Journal:  Exp Cell Res       Date:  2012-01-28       Impact factor: 3.905

4.  The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome.

Authors:  A DerHovanessian; S S Weigt; V Palchevskiy; M Y Shino; D M Sayah; A L Gregson; P W Noble; S M Palmer; M C Fishbein; B M Kubak; A Ardehali; D J Ross; R Saggar; J P Lynch; R M Elashoff; J A Belperio
Journal:  Am J Transplant       Date:  2015-10-13       Impact factor: 8.086

Review 5.  Control of local immunity by airway epithelial cells.

Authors:  M Weitnauer; V Mijošek; A H Dalpke
Journal:  Mucosal Immunol       Date:  2015-12-02       Impact factor: 7.313

6.  TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury.

Authors:  Dorothea M Peters; István Vadász; Lukasz Wujak; Malgorzata Wygrecka; Andrea Olschewski; Christin Becker; Susanne Herold; Rita Papp; Konstantin Mayer; Sebastian Rummel; Ralph P Brandes; Andreas Günther; Siegfried Waldegger; Oliver Eickelberg; Werner Seeger; Rory E Morty
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-09       Impact factor: 11.205

7.  Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice.

Authors:  Huimin Zhang; William E Lawson; Vasiliy V Polosukhin; Ambra Pozzi; Timothy S Blackwell; Ying Litingtung; Chin Chiang
Journal:  Am J Pathol       Date:  2007-08-23       Impact factor: 4.307

8.  Gene expression changes during the development of acute lung injury: role of transforming growth factor beta.

Authors:  Scott C Wesselkamper; Lisa M Case; Lisa N Henning; Michael T Borchers; Jay W Tichelaar; John M Mason; Nadine Dragin; Mario Medvedovic; Maureen A Sartor; Craig R Tomlinson; George D Leikauf
Journal:  Am J Respir Crit Care Med       Date:  2005-08-11       Impact factor: 21.405

9.  The multiple organ dysfunction syndrome and late-phase mortality in sepsis.

Authors:  Joshua A Englert; Mitchell P Fink
Journal:  Curr Infect Dis Rep       Date:  2005-09       Impact factor: 3.725

Review 10.  TGF-β1 Signaling and Tissue Fibrosis.

Authors:  Kevin K Kim; Dean Sheppard; Harold A Chapman
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-04-02       Impact factor: 10.005
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