Literature DB >> 10948171

Transforming growth factor beta1 is expressed in the jejunum after experimental Cryptosporidium parvum infection in humans.

P Robinson1, P C Okhuysen, C L Chappell, D E Lewis, I Shahab, S Lahoti, A C White.   

Abstract

Biopsies from volunteers challenged with Cryptosporidium parvum were examined for transforming growth factor beta1 (TGF-beta1). None of the prechallenge biopsies exhibited TGF-beta. Seven of 12 volunteers with oocyst shedding expressed TGF-beta versus 2 of 13 volunteers without detected oocysts. The association of TGF-beta expression with oocyst excretion and the timing of symptoms suggests that TGF-beta mediates intestinal healing.

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Year:  2000        PMID： 10948171      PMCID： PMC101805          DOI： 10.1128/IAI.68.9.5405-5407.2000

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  28 in total

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5.  Interferon-gamma expression in jejunal biopsies in experimental human cryptosporidiosis correlates with prior sensitization and control of oocyst excretion.

Authors:  A C White; P Robinson; P C Okhuysen; D E Lewis; I Shahab; S Lahoti; H L DuPont; C L Chappell
Journal:  J Infect Dis       Date:  2000-02       Impact factor: 5.226

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  8 in total

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Review 4.  The cell biology of cryptosporidium infection.

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5.  Expression of tumor necrosis factor alpha and interleukin 1 beta in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms.

Authors:  P Robinson; P C Okhuysen; C L Chappell; D E Lewis; I Shahab; A Janecki; A C White
Journal:  Infect Immun       Date:  2001-02       Impact factor: 3.441

6.  Interleukin-4 and transforming growth factor beta have opposing regulatory effects on gamma interferon-mediated inhibition of Cryptosporidium parvum reproduction.

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Review 8.  Infection Strategies of Intestinal Parasite Pathogens and Host Cell Responses.

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  8 in total

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