Literature DB >> 14258734

COXSACKIE A9 VIRUS: MUTATION FROM DRUG DEPENDENCE TO DRUG INDEPENDENCE.

H J EGGERS, I TAMM.   

Abstract

During the multiplication of Coxsackie A9 virus dependent on 2 - (alpha - hydroxybenzyl) - benzimidazole there arise some drug-independent virus particles, which are either drug-resistant or drug-sensitive. We studied the properties of such revertant particles under conditions which did not favor the selection of resistant over sensitive virus particles. These particles exhibited a wide range of responses to 2-(alpha-hydroxybenzyl)-benzimidazole, from high sensitivity to high resistance. Subclones showed the same degree of sensitivity or resistance as the respective parent clones.

Entities:  

Keywords:  BENZIMIDAZOLES; COXSACKIE VIRUSES; DRUG RESISTANCE, MICROBIAL; EXPERIMENTAL LAB STUDY; GUANIDINES; MUTATION; POLIOVIRUS

Mesh：

Substances：

Year:  1965        PMID： 14258734     DOI： 10.1126/science.148.3666.97

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


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