Literature DB >> 14149394

SPLEEN-COLONY FORMATION IN ANEMIC MICE OF GENOTYPE WW.

E A MCCULLOCH, L SIMINOVITCH, J E TILL.   

Abstract

The hemopoietic cells from anemic mice of genotype WW are less able by 200-fold to take part in colony formationin the spleen than cells from the normal littermates of genotype ww. The genetic defect shows itself in the colony-forming cells, since cells from normal littermate mice formcolonies in the spleens of unirradiated mice of genotype WW. Use of animals of genotype WVVWT as recipients improves the spleen-colony method by removing bias resulting fromthe death of irradiated recipients.

Entities:  

Keywords:  ANEMIA, MACROCYTIC; BONE MARROW TRANSPLANTATION; CYTOLOGY; ERYTHROPOIESIS; EXPERIMENTAL LAB STUDY; MICE; RADIATION EFFECTS; RADIATION IMMUNOLOGY; SPLEEN; TISSUE CULTURE; TRANSPLANTATION IMMUNOLOGY

Mesh：

Year:  1964        PMID： 14149394     DOI： 10.1126/science.144.3620.844

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


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