Literature DB >> 10613820

Transplantation of male germ line stem cells restores fertility in infertile mice.

T Ogawa1, I Dobrinski, M R Avarbock, R L Brinster.   

Abstract

Azoospermia or oligozoospermia due to disruption of spermatogenesis are common causes of human male infertility. We used the technique of spermatogonial transplantation in two infertile mouse strains, Steel (Sl) and dominant white spotting (W), to determine if stem cells from an infertile male were capable of generating spermatogenesis. Transplantation of germ cells from infertile Sl/Sld mutant male mice to infertile W/Wv or Wv/W54 mutant male mice restored fertility to the recipient mice. Thus, transplantation of spermatogonial stem cells from an infertile donor to a permissive testicular environment can restore fertility and result in progeny with the genetic makeup of the infertile donor male.

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Year:  2000        PMID： 10613820      PMCID： PMC4879876          DOI： 10.1038/71496

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  42 in total

1.  Long-continued function of normal blood-forming tissue transplanted into genetically anemic hosts.

Authors:  E S RUSSELL; S E BERNSTEIN; F A LAWSON; L J SMITH
Journal:  J Natl Cancer Inst       Date:  1959-09       Impact factor: 13.506

2.  The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.

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Journal:  Cell       Date:  1990-10-05       Impact factor: 41.582

3.  Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant.

Authors:  J G Flanagan; D C Chan; P Leder
Journal:  Cell       Date:  1991-03-08       Impact factor: 41.582

4.  Culture of mouse spermatogonial stem cells.

Authors:  M Nagano; M R Avarbock; E B Leonida; C J Brinster; R L Brinster
Journal:  Tissue Cell       Date:  1998-08       Impact factor: 2.466

5.  Ultrastructural observations of spermatogenesis in mice resulting from transplantation of mouse spermatogonia.

Authors:  L D Russell; L R França; R L Brinster
Journal:  J Androl       Date:  1996 Nov-Dec

6.  Experience with 425 subfertile male patients.

Authors:  S H Greenberg; L I Lipshultz; A J Wein
Journal:  J Urol       Date:  1978-04       Impact factor: 7.450

Review 7.  Hereditary anemias of the mouse: a review for geneticists.

Authors:  E S Russell
Journal:  Adv Genet       Date:  1979       Impact factor: 1.944

8.  Transplantation of germ cells from rabbits and dogs into mouse testes.

Authors:  I Dobrinski; M R Avarbock; R L Brinster
Journal:  Biol Reprod       Date:  1999-11       Impact factor: 4.285

9.  Leuprolide, a gonadotropin-releasing hormone agonist, enhances colonization after spermatogonial transplantation into mouse testes.

Authors:  T Ogawa; I Dobrinski; M R Avarbock; R L Brinster
Journal:  Tissue Cell       Date:  1998-10       Impact factor: 2.466

10.  Spermatogenesis following male germ-cell transplantation.

Authors:  R L Brinster; J W Zimmermann
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-22       Impact factor: 11.205
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  74 in total

1.  Remodeling of the postnatal mouse testis is accompanied by dramatic changes in stem cell number and niche accessibility.

Authors:  T Shinohara; K E Orwig; M R Avarbock; R L Brinster
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-22       Impact factor: 11.205

2.  Restoration of spermatogenesis by lentiviral gene transfer: offspring from infertile mice.

Authors:  Masahito Ikawa; Vinay Tergaonkar; Atsuo Ogura; Narumi Ogonuki; Kimiko Inoue; Inder M Verma
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

Review 3.  Local signalling environments and human male infertility: what we can learn from mouse models.

Authors:  Roopa L Nalam; Martin M Matzuk
Journal:  Expert Rev Mol Med       Date:  2010-05-11       Impact factor: 5.600

Review 4.  Germline stem cell transplantation and transgenesis.

Authors:  Ralph L Brinster
Journal:  Science       Date:  2002-06-21       Impact factor: 47.728

5.  Rats produced by interspecies spermatogonial transplantation in mice and in vitro microinsemination.

Authors:  Takashi Shinohara; Megumi Kato; Masanori Takehashi; Jiyoung Lee; Shinichiro Chuma; Norio Nakatsuji; Mito Kanatsu-Shinohara; Masumi Hirabayashi
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-30       Impact factor: 11.205

6.  Transplantation of spermatogonial stem cells isolated from leukemic mice restores fertility without inducing leukemia.

Authors:  Kazutoshi Fujita; Hiroshi Ohta; Akira Tsujimura; Tetsuya Takao; Yasushi Miyagawa; Shingo Takada; Kiyomi Matsumiya; Teruhiko Wakayama; Akihiko Okuyama
Journal:  J Clin Invest       Date:  2005-06-16       Impact factor: 14.808

Review 7.  Signaling molecules and pathways regulating the fate of spermatogonial stem cells.

Authors:  Zuping He; Maria Kokkinaki; Martin Dym
Journal:  Microsc Res Tech       Date:  2009-08       Impact factor: 2.769

8.  Transgenic mice produced by retroviral transduction of male germ-line stem cells.

Authors:  M Nagano; C J Brinster; K E Orwig; B Y Ryu; M R Avarbock; R L Brinster
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-23       Impact factor: 11.205

9.  Spermatogonial culture medium: an effective and efficient nutrient mixture for culturing rat spermatogonial stem cells.

Authors:  Zhuoru Wu; Ilaria Falciatori; Laura A Molyneux; Timothy E Richardson; Karen M Chapman; F Kent Hamra
Journal:  Biol Reprod       Date:  2009-03-18       Impact factor: 4.285

10.  Genes involved in post-transcriptional regulation are overrepresented in stem/progenitor spermatogonia of cryptorchid mouse testes.

Authors:  Kyle E Orwig; Buom-Yong Ryu; Stephen R Master; Bart T Phillips; Matthias Mack; Mary R Avarbock; Lewis Chodosh; Ralph L Brinster
Journal:  Stem Cells       Date:  2008-01-17       Impact factor: 6.277
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