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Literature DB >> 19270698

Hematopoietic stem cell transplantation without irradiation.

Claudia Waskow¹, Vikas Madan, Susanne Bartels, Céline Costa, Rosel Blasig, Hans-Reimer Rodewald.

Abstract

Hematopoietic stem cell (HSC) transplantation is limited by histocompatibility barriers and by lack of space in bone marrow niches. These obstacles prevent in vivo analysis of histoincompatible mutant stem cells and of HSC functions in non-irradiated mice. By genetically combining immunodeficiency with impaired function of the growth factor receptor Kit in mice, we generated a 'universal' HSC recipient that efficiently accepts long-term histocompatible and histoincompatible HSCs without prior irradiation.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19270698 DOI： 10.1038/nmeth.1309

Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547

15 in total

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3. A novel conditioning-free hematopoietic stem cell transplantation model in zebrafish.

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8. The gp130 Cytokine Interleukin-11 Regulates Engraftment of Vav1^-^/^- Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients.

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