Literature DB >> 1180177

Effect of single and multiple treatments with phenylbutazone in normal and adjuvant-induced polyarthritic rats.

H DiPasquale, C Rassaert, P Welaj, J Gingold.   

Abstract

Liver function alterations, in the adjuvant induced polyarthritis procedure in rats, has been demonstrated by many investigators. We observed a significant inhibition of the polyarthritis with phenylbutazone but we were unable to find any changes in the relative liver weights of SGPT, AP or BUN in polyarthritic or phenylbutazone treated rats. However, we did observe that polyarthritic rats maintained a significantly higher plasma phenylbutazone concentration than the corresponding non-arthritic controls. This appears to futher substantiate the influence of 'pathopharmacodynamics' on the disposition and activity of drugs.

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Year:  1975        PMID： 1180177     DOI： 10.1007/bf02027159

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  27 in total

1.  Adaptation of an alkaline phosphatase method for automatic colorimetric analysis.

Authors:  W H MARSH; B FINGERHUT; E KIRSCH
Journal:  Clin Chem       Date:  1959-04       Impact factor: 8.327

2.  [Action of barbiturates in rats having adjuvant polyarthritis].

Authors:  A Quevauviller; M A Chalchat; H Brouilhet; F Delbarre
Journal:  C R Seances Soc Biol Fil       Date:  1968-10-19

3.  Biochemical changes in rat liver in response to treatment with drugs and other agents. I. Effects of anticonvulsant, anti-inflammatory, hypocholesterolaemic and adrenergic beta-blocking agents.

Authors:  D S Platt; B L Cockrill
Journal:  Biochem Pharmacol       Date:  1969-02       Impact factor: 5.858

4.  The effects of food restriction on hematology, clinical chemistry and pathology in the albino rat.

Authors:  E Schwartz; J A Tornaben; G C Boxill
Journal:  Toxicol Appl Pharmacol       Date:  1973-08       Impact factor: 4.219

5.  Effect of intensive occupational exposure to DDT on phenylbutazone and cortisol metabolism in human subjects.

Authors:  A Poland; D Smith; R Kuntzman; M Jacobson; A H Conney
Journal:  Clin Pharmacol Ther       Date:  1970 Sep-Oct       Impact factor: 6.875

6.  Effects of phenylbutazone on liver microsomal demethylase.

Authors:  A K Cho; B J Hodshon; B B Brodie
Journal:  Biochem Pharmacol       Date:  1970-05       Impact factor: 5.858

7.  Effect of adjuvant disease in rats on cyclophosphamide and isophosphamide metabolism.

Authors:  F J Beck; M W Whitehouse
Journal:  Biochem Pharmacol       Date:  1973-10-01       Impact factor: 5.858

Review 8.  Impaired drug metabolism in rats with adjuvant-induced arthritis: a brief review.

Authors:  M W Whitehouse; F J Beck
Journal:  Drug Metab Dispos       Date:  1973 Jan-Feb       Impact factor: 3.922

9.  Untoward effects of phenylbutazone (butazolidin)-a re-evaluation.

Authors:  I L SPERLING
Journal:  Arthritis Rheum       Date:  1959-06

10.  CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT.

Authors:  B B NEWBOULD
Journal:  Br J Pharmacol Chemother       Date:  1963-08
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  2 in total

1.  Anti-inflammatory activity of isoxicam in combination with aspirin or D-propoxyphene.

Authors:  G DiPasquale; C Rassaert; P Welaj; L Tripp
Journal:  Agents Actions       Date:  1976-11

2.  Depression of drug metabolism in the mouse by a combination of Mycobacterium butyricum and anaesthetics.

Authors:  E J Barbieri; E I Ciaccio
Journal:  Br J Pharmacol       Date:  1979-01       Impact factor: 8.739
  2 in total

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