Literature DB >> 140146

Anomalous cellular proliferation in vitro associated with Huntington's disease.

D Kirk, J M Parrington, G Corney, J M Bolt.   

Abstract

Detailed growth analyses of cultured skin fibroblasts from two patients with Huntington's Disease (HD) were compared with those from controls matched for age and sex. In contrast to control cells, HD fibroblasts plated more efficiently at the low seeding densities used. Subsequent exponential growth of HD cultures was more stable towards routine trypsinisation than that of controls. However, the most striking feature of HD cultures was their ability to grow to significantly higher cell saturation densities. Experiments with trypsinised and untrypsinised cultures imply an inherent alteration in the HD cell membrane.

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Year:  1977        PMID： 140146     DOI： 10.1007/bf00273252

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  10 in total

1.  Fibroblasts in Huntington's disease.

Authors:  I Goetz; E Roberts; D E Comings
Journal:  N Engl J Med       Date:  1975-12-11       Impact factor: 91.245

2.  Specific chromosome aberrations in ataxia telangiectasia.

Authors:  J M Oxford; D G Harnden; J M Parrington; J D Delhanty
Journal:  J Med Genet       Date:  1975-09       Impact factor: 6.318

3.  Cytogenetically marked clones in human fibroblasts cultured from normal subjects.

Authors:  D G Harnden; P A Benn; J M Oxford; A M Taylor; T P Webb
Journal:  Somatic Cell Genet       Date:  1976-01

4.  The Gardner syndrome: increased tetraploidy in cultured skin fibroblast.

Authors:  B S Danes
Journal:  J Med Genet       Date:  1976-02       Impact factor: 6.318

5.  Growth control and cyclic alterations of cyclic AMP in the cell cycle.

Authors:  M M Burger; B M Bombik; B M Breckenridge; J R Sheppard
Journal:  Nat New Biol       Date:  1972-10-11

6.  Huntington's chorea. A study of liver function and histology.

Authors:  J M Bolt; G P Lewis
Journal:  Q J Med       Date:  1973-01

7.  Fibroblast cultures in Huntington's disease.

Authors:  J H Menkes; N Stein
Journal:  N Engl J Med       Date:  1973-04-19       Impact factor: 91.245

8.  Lymphocytes: circulation altered by trypsin.

Authors:  J Woodruff; B M Gesner
Journal:  Science       Date:  1968-07-12       Impact factor: 47.728

9.  The establishment of criteria for "quiescence" in ageing human embryo cell cultures and their response to a proliferative stimulus.

Authors:  B T Hill
Journal:  Gerontology       Date:  1977       Impact factor: 5.140

10.  A simple cytochemical technique for demonstration of DNA in cells infected with mycoplasmas and viruses.

Authors:  W C Russell; C Newman; D H Williamson
Journal:  Nature       Date:  1975-02-06       Impact factor: 49.962
  10 in total
  9 in total

1.  Qualitative and quantitative study of the growth and cell surface properties of Huntington's disease fibroblasts and age-matched controls. Lack of significant differences.

Authors:  J J Cassiman; J Verlinden; R F Vlietinck; J Bellemans; F Van Leuven; J Deroover; F Baro; H Van den Berghe
Journal:  Hum Genet       Date:  1979       Impact factor: 4.132

2.  Sensitivity to ionising radiation of lymphocytes from Huntington's chorea patients compared to controls.

Authors:  D McGovern; T Webb
Journal:  J Med Genet       Date:  1982-06       Impact factor: 6.318

3.  Studies on erythrocyte membranes of patients with Huntington's disease.

Authors:  T M Dubbelman; A W de Bruijne; J Van Steveninck; G W Bruyn
Journal:  J Neurol Neurosurg Psychiatry       Date:  1981-07       Impact factor: 10.154

Review 4.  The current state of research with peripheral tissues in Huntington disease.

Authors:  G C Beverstock
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

5.  The ups and downs of Huntington disease research.

Authors:  D E Comings
Journal:  Am J Hum Genet       Date:  1981-03       Impact factor: 11.025

Review 6.  Huntington disease: genetics and epidemiology.

Authors:  P M Conneally
Journal:  Am J Hum Genet       Date:  1984-05       Impact factor: 11.025

7.  Huntington disease and Tourette syndrome. I. Electron spin resonance of bed ghosts.

Authors:  D E Comings; A Pekkala; J R Schuh; P C Kuo; S I Chan
Journal:  Am J Hum Genet       Date:  1981-03       Impact factor: 11.025

8.  Skin fibroblasts in Huntington disease.

Authors:  I E Goetz; E Roberts; J Warren
Journal:  Am J Hum Genet       Date:  1981-03       Impact factor: 11.025

9.  A patient-derived cellular model for Huntington's disease reveals phenotypes at clinically relevant CAG lengths.

Authors:  Claudia Lin-Kar Hung; Tamara Maiuri; Laura Erin Bowie; Ryan Gotesman; Susie Son; Mina Falcone; James Victor Giordano; Tammy Gillis; Virginia Mattis; Trevor Lau; Vickie Kwan; Vanessa Wheeler; Jonathan Schertzer; Karun Singh; Ray Truant
Journal:  Mol Biol Cell       Date:  2018-09-26       Impact factor: 4.138
  9 in total

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