Literature DB >> 1394630

Synthesis and antibacterial activity of some imidazo[1,2-a]pyrimidine derivatives.

Y Rival1, G Grassy, G Michel.   

Abstract

A series of 75 imidazo[1,2-a]pyrimidine derivatives were synthesized. The "in vitro" antibacterial activity of these compounds and their corresponding alpha-bromoketones against a variety of gram (+), gram (-) bacteria and Mycobacterium species is reported. Some of the prepared derivatives exhibited potent antimicrobial activity.

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Year:  1992        PMID： 1394630     DOI： 10.1248/cpb.40.1170

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  17 in total

1.  Microwave-assisted synthesis of a 3-aminoimidazo[1,2-a]-pyridine/pyrazine library by fluorous multicomponent reactions and subsequent cross-coupling reactions.

Authors:  Yimin Lu; Wei Zhang
Journal:  QSAR Comb Sci       Date:  2004

2.  One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br(3) and 2-aminopyridine under solvent-free conditions.

Authors:  Zhang-Gao Le; Zong-Bo Xie; Jian-Ping Xu
Journal:  Molecules       Date:  2012-11-09       Impact factor: 4.411

3.  Ι₂-mediated amination/cyclization of ketones with 2-aminopyridines under high-speed ball milling: solvent- and metal-free synthesis of 2,3-substituted imidazo[1,2-a]pyridines and zolimidine.

Authors:  Fang-Jian Wang; Hui Xu; Ming Xin; Ze Zhang
Journal:  Mol Divers       Date:  2016-03-14       Impact factor: 2.943

4.  Gold Catalysed Redox Synthesis of Imidazo[1,2-a]pyridine using Pyridine N-Oxide and Alkynes.

Authors:  Eric P A Talbot; Melodie Richardson; Jeffrey M McKenna; F Dean Toste
Journal:  Adv Synth Catal       Date:  2014-03-10       Impact factor: 5.837

5.  2-Amino-5-nitro-pyridinium tri-fluoro-acetate.

Authors:  Josephine Viavulamary Jovita; Shanmugam Sathya; Govindasamy Usha; Ramachandran Vasanthi; Krishnan Sarada Ezhilarasi
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-05-11

6.  Ethyl 8-amino-6-bromoimidazo[1,2-a]pyridine-2-carb-oxy-late.

Authors:  Siham Dahmani; Youssef Kandri Rodi; Santiago V Luis; El Mokhtar Essassi; Lahcen El Ammari
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-05-11

7.  Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.

Authors:  Lisa Yu; Andres Lopez; Abderrahmane Anaflous; Brahim El Bali; Abdellah Hamal; Elke Ericson; Lawrence E Heisler; Angus McQuibban; Guri Giaever; Corey Nislow; Charles Boone; Grant W Brown; Mohammed Bellaoui
Journal:  PLoS Genet       Date:  2008-11-28       Impact factor: 5.917

8.  The pseudo-Michael reaction of 1-aryl-4,5-dihydro-1H-imidazol-2-amines with ethyl ethoxymethylenecyanoacetate.

Authors:  Agnieszka A Kaczor; Urszula Kijkowska-Murak; Kalevi Pihlaja; Jari Sinkkonen; Waldemar Wysocki; Zbigniew Karczmarzyk; Dariusz Matosiuk
Journal:  Monatsh Chem       Date:  2013-05-14       Impact factor: 1.451

9.  Synthesis, central nervous system activity, and structure-activity relationship of 1-aryl-6-benzyl-7-hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1H)-ones.

Authors:  Marzena Rządkowska; Elżbieta Szacoń; Agnieszka A Kaczor; Sylwia Fidecka; Ewa Kędzierska; Dariusz Matosiuk
Journal:  Med Chem Res       Date:  2014-03-27       Impact factor: 1.965

10.  Microwave assisted synthesis of bis and tris(ω-bromoacetophenones): versatile precursors for novel bis(imidazo[1,2-a]pyridines), bis(imidazo[1,2-a]pyrimidines) and their tris-analogs.

Authors:  Mohamed R Shaaban
Journal:  Chem Cent J       Date:  2013-06-19       Impact factor: 4.215
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