Literature DB >> 17770204

BACITRACIN: A NEW ANTIBIOTIC PRODUCED BY A MEMBER OF THE B. SUBTILIS GROUP.

B A Johnson, H Anker, F L Meleney.   

Abstract

A new antibiotic "bacitracin" has been recovered from a strain of the B. subtilis group of organisms. It is neutral, water-soluble, non-toxic and relatively heat stable. In vitro it is active chiefly against Grampositive organisms, but the gonococcus and meningococcus are susceptible to its action. It is also active in vivo against experimentally produced hemolytic streptococcal infections in mice and gas gangrene infections in guinea pigs. Clinical use in hemolytic streptococcal and staphylococcal infections in man have given encouraging results.

Entities:  

Year:  1945        PMID： 17770204     DOI： 10.1126/science.102.2650.376

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  59 in total

1.  THE ISOLATION OF ACTIVE PRINCIPLES IN PURE FORM BY PARTITION.

Authors:  L C CRAIG
Journal:  Bull N Y Acad Med       Date:  1963-11

2.  [Combined bacitracin and hemolysis inhibition test in practical group differentiation of hemolyzing streptococci].

Authors:  K E SCHNEWEIS; A NIKFETRAT
Journal:  Z Hyg Infektionskr       Date:  1959

3.  Requirement of divalent metal ions for bacitracin activity.

Authors:  R H ADLER; J E SNOKE
Journal:  J Bacteriol       Date:  1962-06       Impact factor: 3.490

4.  [Bacitracin test, a simple method for determination of group A hemolytic streptococci].

Authors:  H LOFFLER
Journal:  Z Hyg Infektionskr       Date:  1954

5.  [Research technics in the discovery of new antibiotics].

Authors:  F LINDNER; K H WALLHAUSSER
Journal:  Arch Mikrobiol       Date:  1955

6.  The use of bacitracin for identifying group A haemolytic streptococci.

Authors:  W R MAXTED
Journal:  J Clin Pathol       Date:  1953-08       Impact factor: 3.411

7.  THE USE OF ANTIBIOTICS IN SURGICAL PRACTICE.

Authors:  H L Silvani
Journal:  Calif Med       Date:  1947-09

8.  Studies on Polymyxin: Isolation and Identification of Bacillus polymyxa and Differentiation of Polymyxin from Certain Known Antibiotics.

Authors:  P G Stansly; M E Schlosser
Journal:  J Bacteriol       Date:  1947-11       Impact factor: 3.490

9.  The Relative Antisyphilitic Activity of Penicillins F, G, K, and X and of Bacitracin, Based on the Amounts Required to Abort Early Syphilitic Infections in Rabbits.

Authors:  H Eagle; R Fleischman
Journal:  J Bacteriol       Date:  1948-03       Impact factor: 3.490

10.  Whole-Genome Sequence Analysis of Paenibacillus alvei JR949 Revealed Biosynthetic Gene Clusters Coding for Novel Antimicrobials.

Authors:  Parameswaran Sree Pranav; Balasubramanian Mahalakshmi; Ramamoorthy Sivakumar; Raman Karthikeyan; Jeyaprakash Rajendhran
Journal:  Curr Microbiol       Date:  2021-02-22       Impact factor: 2.188
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