Literature DB >> 1385221

Osteoclasts express high levels of p60c-src, preferentially on ruffled border membranes.

S Tanaka1, N Takahashi, N Udagawa, T Sasaki, Y Fukui, T Kurokawa, T Suda.   

Abstract

Expression of p60c-src, the normal cellular counterpart of the transforming protein of Rous sarcoma virus (RSV), p60v-src, was examined in mouse and rat authentic osteoclasts and mouse osteoclast-like multinucleated cells (MNCs) formed in vitro. In co-cultures of mouse osteoblastic cells and spleen cells, the expression of p60c-src strikingly increased on day 5 in parallel with the appearance of MNCs in the presence of 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25(OH)2D3). Immunohistochemical examination confirmed the high level expression of p60c-src in both mouse authentic osteoclasts and MNCs. Electron microscopic examination revealed that p60c-src was primarily localized on ruffled border membranes and vacuoles, but not on the clear zone in rat authentic osteoclasts. These results suggest that p60c-src is important in osteoclastic bone resorption.

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Year:  1992        PMID： 1385221     DOI： 10.1016/0014-5793(92)81190-w

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  19 in total

1.  Parathyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade.

Authors:  I A Nakchbandi; E E Weir; K L Insogna; W M Philbrick; A E Broadus
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-20       Impact factor: 11.205

Review 2.  RNA therapeutics targeting osteoclast-mediated excessive bone resorption.

Authors:  Yuwei Wang; David W Grainger
Journal:  Adv Drug Deliv Rev       Date:  2011-09-10       Impact factor: 15.470

3.  Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor.

Authors:  Y Abu-Amer; F P Ross; J Edwards; S L Teitelbaum
Journal:  J Clin Invest       Date:  1997-09-15       Impact factor: 14.808

4.  c-Src control of chloride channel support for osteoclast HCl transport and bone resorption.

Authors:  John C Edwards; Christopher Cohen; Weibing Xu; Paul H Schlesinger
Journal:  J Biol Chem       Date:  2006-07-10       Impact factor: 5.157

Review 5.  A novel miR17/protein tyrosine phosphatase-oc/EphA4 regulatory axis of osteoclast activity.

Authors:  Kin-Hing William Lau; Matilda H-C Sheng
Journal:  Arch Biochem Biophys       Date:  2018-05-17       Impact factor: 4.013

6.  Porphyromonas gingivalis fimbria-stimulated bone resorption in vitro is inhibited by a tyrosine kinase inhibitor.

Authors:  S Hanazawa; Y Kawata; Y Murakami; K Naganuma; S Amano; Y Miyata; S Kitano
Journal:  Infect Immun       Date:  1995-06       Impact factor: 3.441

7.  Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts.

Authors:  H Takayanagi; T Juji; T Miyazaki; H Iizuka; T Takahashi; M Isshiki; M Okada; Y Tanaka; Y Koshihara; H Oda; T Kurokawa; K Nakamura; S Tanaka
Journal:  J Clin Invest       Date:  1999-07       Impact factor: 14.808

8.  PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase.

Authors:  L T Duong; P T Lakkakorpi; I Nakamura; M Machwate; R M Nagy; G A Rodan
Journal:  J Clin Invest       Date:  1998-09-01       Impact factor: 14.808

9.  Architecture and distribution of cancellous bone yield vertebral fracture clues. A histomorphometric analysis of the complete spinal column from 40 autopsy specimens.

Authors:  M Amling; M Pösl; H Ritzel; M Hahn; M Vogel; V J Wening; G Delling
Journal:  Arch Orthop Trauma Surg       Date:  1996       Impact factor: 3.067

10.  A novel monoclonal antibody recognizing a unique antigen of rat osteoclasts induced by the calcified matrices.

Authors:  K Hata; T Kukita; A Akamine; A Kukita; K Kurisu; T Iijima
Journal:  Histochemistry       Date:  1994-06
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