Literature DB >> 1382040

Enhancement of trinitrophenyl-specific humoral response to TNP proteins as the result of carrier chlorination.

J Marcinkiewicz1, E Olszowska, S Olszowski, J M Zgliczynski.   

Abstract

Trinitrophenyl (TNP)-specific humoral response was tested after immunization with TNP-protein conjugates composed of either native proteins or proteins modified by chlorination. Significant enhancement of the hapten-specific response was observed as a result of carrier chlorination. This effect was dose dependent and affected mainly T-helper-cell activation. Since stimulated neutrophils chlorinate in vivo proteins, we propose that they take part in the induction phase of immune response by facilitation of antigen processing and/or presentation.

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Year:  1992        PMID： 1382040      PMCID： PMC1421697     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  10 in total

1.  The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.

Authors:  N A Mitchison
Journal:  Eur J Immunol       Date:  1971-01       Impact factor: 5.532

2.  Enhancement of proteinase-mediated degradation of proteins modified by chlorination.

Authors:  E Olszowska; S Olszowski; J M Zgliczyński; T Stelmaszyńska
Journal:  Int J Biochem       Date:  1989

3.  Chlorinating ability of human phagocytosing leucocytes.

Authors:  J M Zgliczyński; T Stelmaszyńska
Journal:  Eur J Biochem       Date:  1975-08-01

4.  Enhancement of immunogenic properties of ovalbumin as a result of its chlorination.

Authors:  J Marcinkiewicz; B M Chain; E Olszowska; S Olszowski; J M Zgliczyński
Journal:  Int J Biochem       Date:  1991

Review 5.  T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex.

Authors:  R H Schwartz
Journal:  Annu Rev Immunol       Date:  1985       Impact factor: 28.527

Review 6.  Antigen-presenting function of the macrophage.

Authors:  E R Unanue
Journal:  Annu Rev Immunol       Date:  1984       Impact factor: 28.527

Review 7.  The biochemistry and cell biology of antigen processing.

Authors:  B M Chain; P M Kaye; M A Shaw
Journal:  Immunol Rev       Date:  1988-12       Impact factor: 12.988

8.  Induction of suppressor cells and cells producing antigen-specific suppressor factors by haptens bound to self carriers.

Authors:  W Ptak; D Rózycka; M Rewicka
Journal:  Immunobiology       Date:  1980-01       Impact factor: 3.144

9.  Oxidation of lysine side-chains of elastin by the myeloperoxidase system and by stimulated human neutrophils.

Authors:  R A Clark; S Szot; M A Williams; H M Kagan
Journal:  Biochem Biophys Res Commun       Date:  1986-03-13       Impact factor: 3.575

10.  Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

Authors:  D J Cher; T R Mosmann
Journal:  J Immunol       Date:  1987-06-01       Impact factor: 5.422
  10 in total
  7 in total

Review 1.  Whole tumor antigen vaccines.

Authors:  Cheryl Lai-Lai Chiang; Fabian Benencia; George Coukos
Journal:  Semin Immunol       Date:  2010-03-30       Impact factor: 11.130

2.  Regulation of murine dendritic cell functions in vitro by taurine chloramine, a major product of the neutrophil myeloperoxidase-halide system.

Authors:  J Marcinkiewicz; B Nowak; A Grabowska; M Bobek; L Petrovska; B Chain
Journal:  Immunology       Date:  1999-11       Impact factor: 7.397

3.  Differential effects of chlorination of bacteria on their capacity to generate NO, TNF-alpha and IL-6 in macrophages.

Authors:  J Marcinkiewicz; B Czajkowska; A Grabowska; A Kasprowicz; B Kociszewska
Journal:  Immunology       Date:  1994-12       Impact factor: 7.397

4.  Oxidation of defined antigens allows protein unfolding and increases both proteolytic processing and exposes peptide epitopes which are recognized by specific T cells.

Authors:  E Carrasco-Marín; J E Paz-Miguel; P López-Mato; C Alvarez-Domínguez; F Leyva-Cobián
Journal:  Immunology       Date:  1998-11       Impact factor: 7.397

5.  Modulation of antigen-specific T-cell activation in vitro by taurine chloramine.

Authors:  J Marcinkiewicz; A Grabowska; B M Chain
Journal:  Immunology       Date:  1998-07       Impact factor: 7.397

Review 6.  Personalized Dendritic Cell Vaccines-Recent Breakthroughs and Encouraging Clinical Results.

Authors:  Beatris Mastelic-Gavillet; Klara Balint; Caroline Boudousquie; Philippe O Gannon; Lana E Kandalaft
Journal:  Front Immunol       Date:  2019-04-11       Impact factor: 7.561

7.  A Phase I vaccine trial using dendritic cells pulsed with autologous oxidized lysate for recurrent ovarian cancer.

Authors:  Lana E Kandalaft; Cheryl L Chiang; Janos Tanyi; Greg Motz; Klara Balint; Rosemarie Mick; George Coukos
Journal:  J Transl Med       Date:  2013-06-18       Impact factor: 5.531
  7 in total

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