Literature DB >> 3008720

Oxidation of lysine side-chains of elastin by the myeloperoxidase system and by stimulated human neutrophils.

R A Clark, S Szot, M A Williams, H M Kagan.   

Abstract

Exposure of [3H]-lysine labeled elastin to either purified myeloperoxidase plus H2O2 and halides or human neutrophils plus phorbol myristate acetate resulted in oxidation of lysine side chains quantitated as 3H2O release. In both the enzyme and cell system oxidation was blocked by azide, cyanide or catalase, but not by beta-aminopropionitrile, an inhibitor of lysyl oxidase. Myeloperoxidase-deficient neutrophils were ineffective unless exogenous myeloperoxidase was added. These data provide a biochemical basis for inflammatory changes in connective tissue proteins mediated by oxidant secretory products of neutrophils.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3008720     DOI： 10.1016/0006-291x(86)90015-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

1.  Enhancement of trinitrophenyl-specific humoral response to TNP proteins as the result of carrier chlorination.

Authors:  J Marcinkiewicz; E Olszowska; S Olszowski; J M Zgliczynski
Journal:  Immunology       Date:  1992-07       Impact factor: 7.397

2.  Action of hypochlorous acid on the antioxidant protective enzymes superoxide dismutase, catalase and glutathione peroxidase.

Authors:  O I Aruoma; B Halliwell
Journal:  Biochem J       Date:  1987-12-15       Impact factor: 3.857

3.  Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo.

Authors:  Hongqiao Lin; Bruce S Levison; Jennifer A Buffa; Ying Huang; Xiaoming Fu; Zeneng Wang; Valentin Gogonea; Joseph A DiDonato; Stanley L Hazen
Journal:  Free Radic Biol Med       Date:  2017-01-06       Impact factor: 7.376

4.  Time-dependent inhibition of oxygen radical induced lung injury.

Authors:  D E Gannon; X M He; P A Ward; J Varani; K J Johnson
Journal:  Inflammation       Date:  1990-10       Impact factor: 4.092

5.  Hypochlorite-induced oxidation of proteins in plasma: formation of chloramines and nitrogen-centred radicals and their role in protein fragmentation.

Authors:  C L Hawkins; M J Davies
Journal:  Biochem J       Date:  1999-06-01       Impact factor: 3.857

6.  Oxidative and nitrosative modifications of tropoelastin prevent elastic fiber assembly in vitro.

Authors:  Kamal Akhtar; Thomas J Broekelmann; Ming Miao; Fred W Keeley; Barry C Starcher; Richard A Pierce; Robert P Mecham; Tracy L Adair-Kirk
Journal:  J Biol Chem       Date:  2010-09-16       Impact factor: 5.157

7.  Reaction of protein chloramines with DNA and nucleosides: evidence for the formation of radicals, protein-DNA cross-links and DNA fragmentation.

Authors:  Clare L Hawkins; David I Pattison; Michael J Davies
Journal:  Biochem J       Date:  2002-08-01       Impact factor: 3.857

8.  Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein. A mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsaturated aldehydes by phagocytes at sites of inflammation.

Authors:  M M Anderson; S L Hazen; F F Hsu; J W Heinecke
Journal:  J Clin Invest       Date:  1997-02-01       Impact factor: 14.808

9.  Hypochlorite-induced damage to proteins: formation of nitrogen-centred radicals from lysine residues and their role in protein fragmentation.

Authors:  C L Hawkins; M J Davies
Journal:  Biochem J       Date:  1998-06-15       Impact factor: 3.857

10.  Comparative study of HOCl-inflicted damage to bacterial DNA ex vivo and within cells.

Authors:  Christine Suquet; Jeffrey J Warren; Nimulrith Seth; James K Hurst
Journal:  Arch Biochem Biophys       Date:  2009-10-20       Impact factor: 4.013
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.