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Literature DB >> 1380506

The mitochondrial benzodiazepine receptor: evidence for association with the voltage-dependent anion channel (VDAC).

Abstract

Specific, high-affinity receptors for numerous drugs have recently been localized to mitochondrial membrane proteins. This review discusses the association of the mitochondrial receptor for benzodiazepines (mBzR) with the voltage-dependent anion channel (VDAC), indicating a possible auxiliary role for VDAC as a putative drug binding protein. The proposed subunit composition of the purified mBzR complex isolated from rat kidney mitochondria includes VDAC, which functions as a recognition site for benzodiazepines (e.g., flunitrazepam), the adenine nucleotide carrier (ADC), and an 18 kDa outer membrane protein identified by covalent labelling with the mBzR antagonists isoquinoline carboxamides (e.g., PK14105).

Entities: Chemical Gene Species

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Year: 1992 PMID： 1380506 DOI： 10.1007/bf00769532

Source DB: PubMed Journal: J Bioenerg Biomembr ISSN： 0145-479X Impact factor: 2.945

74 in total

1. Effect of ADP/ATP antiporter conformational state on the suppression of the nonspecific permeability of the inner mitochondrial membrane by cyclosporine A.

Authors: S A Novgorodov; T I Gudz; Y E Kushnareva; D B Zorov; Y B Kudrjashov
Journal: FEBS Lett Date: 1990-12-17 Impact factor: 4.124

2. Immunological studies on the rat peripheral-type benzodiazepine acceptor.

Authors: P N Moynagh; C J Bailey; S J Boyce; D C Williams
Journal: Biochem J Date: 1991-04-15 Impact factor: 3.857

Review 3. Widening potential for Ca2+ antagonists: non-L-type Ca2+ channel interaction.

Authors: G Zernig
Journal: Trends Pharmacol Sci Date: 1990-01 Impact factor: 14.819

4. Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers.

Authors: A R Safa; C J Glover; J L Sewell; M B Meyers; J L Biedler; R L Felsted
Journal: J Biol Chem Date: 1987-06-05 Impact factor: 5.157

5. Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC.

Authors: R A Nakashima; P S Mangan; M Colombini; P L Pedersen
Journal: Biochemistry Date: 1986-03-11 Impact factor: 3.162

Review 6. Peripheral-type benzodiazepine receptors: a second site of action for benzodiazepines.

Authors: K E Krueger
Journal: Neuropsychopharmacology Date: 1991-06 Impact factor: 7.853

7. Release of Ca2+ from heart and kidney mitochondria by peripheral-type benzodiazepine receptor ligands.

Authors: R Moreno-Sánchez; C Bravo; J Gutiérrez; A H Newman; P K Chiang
Journal: Int J Biochem Date: 1991

8. Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor. Evidence for an outer mitochondrial membrane location.

Authors: D M Parry; P L Pedersen
Journal: J Biol Chem Date: 1983-09-25 Impact factor: 5.157

9. Benzodiazepine receptor-mediated chemotaxis of human monocytes.

Authors: M R Ruff; C B Pert; R J Weber; L M Wahl; S M Wahl; S M Paul
Journal: Science Date: 1985-09-20 Impact factor: 47.728

Review 10. Receptors for the age of anxiety: pharmacology of the benzodiazepines.

Authors: J F Tallman; S M Paul; P Skolnick; D W Gallager
Journal: Science Date: 1980-01-18 Impact factor: 47.728

22 in total

Review 1. The peripheral benzodiazepine receptors: a review.

Authors: A Beurdeley-Thomas; L Miccoli; S Oudard; B Dutrillaux; M F Poupon
Journal: J Neurooncol Date: 2000 Impact factor: 4.130

Review 2. The emerging picture of mitochondrial membrane channels.

Authors: C A Mannella; H Tedeschi
Journal: J Bioenerg Biomembr Date: 1992-02 Impact factor: 2.945

Review 3. The voltage-dependent anion channel in endoplasmic/sarcoplasmic reticulum: characterization, modulation and possible function.

Authors: V Shoshan-Barmatz; A Israelson
Journal: J Membr Biol Date: 2005-03 Impact factor: 1.843

The mitochondrial benzodiazepine receptor: evidence for association with the voltage-dependent anion channel (VDAC).

1. Effect of ADP/ATP antiporter conformational state on the suppression of the nonspecific permeability of the inner mitochondrial membrane by cyclosporine A.

2. Immunological studies on the rat peripheral-type benzodiazepine acceptor.

Review 3. Widening potential for Ca2+ antagonists: non-L-type Ca2+ channel interaction.

4. Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers.

5. Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC.

Review 6. Peripheral-type benzodiazepine receptors: a second site of action for benzodiazepines.

7. Release of Ca2+ from heart and kidney mitochondria by peripheral-type benzodiazepine receptor ligands.

8. Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor. Evidence for an outer mitochondrial membrane location.

9. Benzodiazepine receptor-mediated chemotaxis of human monocytes.

Review 10. Receptors for the age of anxiety: pharmacology of the benzodiazepines.

Review 1. The peripheral benzodiazepine receptors: a review.

Review 2. The emerging picture of mitochondrial membrane channels.

Review 3. The voltage-dependent anion channel in endoplasmic/sarcoplasmic reticulum: characterization, modulation and possible function.

Review 4. Electrophysiology of the inner mitochondrial membrane.

5. Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands.

Review 6. Eubacterial signal transduction by ligands of the mammalian peripheral benzodiazepine receptor complex.

7. Proteins of cytosol and amniotic fluid increase the voltage dependence of human type-1 porin.

Review 8. Perspectives on the mitochondrial multiple conductance channel.

Review 9. Inhibition of mitochondrial membrane permeability as a putative pharmacological target for cardioprotection.

Review 10. Regulation of hexokinase binding to VDAC.