Literature DB >> 1376925

Expression cloning of a cDNA from rabbit kidney cortex that induces a single transport system for cystine and dibasic and neutral amino acids.

J Bertran1, A Werner, M L Moore, G Stange, D Markovich, J Biber, X Testar, A Zorzano, M Palacin, H Murer.   

Abstract

We have isolated a cDNA clone by screening a rabbit kidney cortex cDNA library for expression of sodium-independent transport of L-arginine and L-alanine in Xenopus laevis oocytes. Expressed uptake relates to a single component of sodium-independent transport for dibasic and neutral amino acids. This transport activity resembles the functionally defined system b0,+ and carries cystine and dibasic amino acids with high affinity. The rBAT (b0,+ amino acid transporter-related) mRNA is found mainly in kidney and intestinal mucosa. It encodes a predicted 77.8-kDa protein with only one putative transmembrane domain and seven potential N-glycosylation sites. This protein could either be a constitutive element or a specific activator of system b0,+.

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Year:  1992        PMID： 1376925      PMCID： PMC49340          DOI： 10.1073/pnas.89.12.5601

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  Signal recognition particle mediates the insertion of a transmembrane protein which has a cytoplasmic NH2 terminus.

Authors:  E C Holland; K Drickamer
Journal:  J Biol Chem       Date:  1986-01-25       Impact factor: 5.157

2.  Expression cloning and cDNA sequencing of the Na+/glucose co-transporter.

Authors:  M A Hediger; M J Coady; T S Ikeda; E M Wright
Journal:  Nature       Date:  1987 Nov 26-Dec 2       Impact factor: 49.962

3.  A salivary gland-specific, maltase-like gene of the vector mosquito, Aedes aegypti.

Authors:  A A James; K Blackmer; J V Racioppi
Journal:  Gene       Date:  1989-01-30       Impact factor: 3.688

4.  Cloning of a membrane protein that induces a slow voltage-gated potassium current.

Authors:  T Takumi; H Ohkubo; S Nakanishi
Journal:  Science       Date:  1988-11-18       Impact factor: 47.728

5.  Sequence and structure of a human glucose transporter.

Authors:  M Mueckler; C Caruso; S A Baldwin; M Panico; I Blench; H R Morris; W J Allard; G E Lienhard; H F Lodish
Journal:  Science       Date:  1985-09-06       Impact factor: 47.728

6.  Characterization of neutral and cationic amino acid transport in Xenopus oocytes.

Authors:  M J Campa; M S Kilberg
Journal:  J Cell Physiol       Date:  1989-12       Impact factor: 6.384

7.  Cloning and expression of cDNA for a Na/Pi cotransport system of kidney cortex.

Authors:  A Werner; M L Moore; N Mantei; J Biber; G Semenza; H Murer
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-01       Impact factor: 11.205

8.  Expression of rat jejunal cystine carrier in Xenopus oocytes.

Authors:  P D McNamara; C T Rea; S Segal
Journal:  J Biol Chem       Date:  1991-01-15       Impact factor: 5.157

9.  Na+-independent transport of basic and zwitterionic amino acids in mouse blastocysts by a shared system and by processes which distinguish between these substrates.

Authors:  L J Van Winkle; A L Campione; J M Gorman
Journal:  J Biol Chem       Date:  1988-03-05       Impact factor: 5.157

Review 10.  The scanning model for translation: an update.

Authors:  M Kozak
Journal:  J Cell Biol       Date:  1989-02       Impact factor: 10.539
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  56 in total

1.  Cloning of a rat kidney cDNA that stimulates dibasic and neutral amino acid transport and has sequence similarity to glucosidases.

Authors:  R G Wells; M A Hediger
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

2.  Chinese hamster ovary mRNA-dependent, Na(+)-independent L-leucine transport in Xenopus laevis oocytes.

Authors:  T Z Su; C D Logsdon; D L Oxender
Journal:  Mol Cell Biol       Date:  1992-12       Impact factor: 4.272

3.  The light subunit of system b(o,+) is fully functional in the absence of the heavy subunit.

Authors:  Núria Reig; Josep Chillarón; Paola Bartoccioni; Esperanza Fernández; Annie Bendahan; Antonio Zorzano; Baruch Kanner; Manuel Palacín; Joan Bertran
Journal:  EMBO J       Date:  2002-09-16       Impact factor: 11.598

4.  Urinary excretion of total cystine and the dibasic amino acids arginine, lysine and ornithine in relation to genetic findings in patients with cystinuria treated with sulfhydryl compounds.

Authors:  Erik Fjellstedt; Lotta Harnevik; Jan-Olof Jeppsson; Hans-Göran Tiselius; Peter Söderkvist; Torsten Denneberg
Journal:  Urol Res       Date:  2003-10-25

5.  Regulation of CAT: Cationic amino acid transporter gene expression.

Authors:  C L Macleod; D K Kakuda
Journal:  Amino Acids       Date:  1996-06       Impact factor: 3.520

6.  Expression cloning of the cDNA for a polypeptide associated with rat hepatic sinusoidal reduced glutathione transport: characteristics and comparison with the canalicular transporter.

Authors:  J R Yi; S Lu; J Fernández-Checa; N Kaplowitz
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

7.  Transport characteristics of a murine renal Na/Pi-cotransporter.

Authors:  C M Hartmann; C A Wagner; A E Busch; D Markovich; J Biber; F Lang; H Murer
Journal:  Pflugers Arch       Date:  1995-09       Impact factor: 3.657

8.  Amino acid transport system y+L of human erythrocytes: specificity and cation dependence of the translocation step.

Authors:  S Angelo; R Devés
Journal:  J Membr Biol       Date:  1994-08       Impact factor: 1.843

9.  Cloning and chromosomal localization of a human kidney cDNA involved in cystine, dibasic, and neutral amino acid transport.

Authors:  W S Lee; R G Wells; R V Sabbag; T K Mohandas; M A Hediger
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

10.  Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions.

Authors:  A E Busch; A Schuster; S Waldegger; C A Wagner; G Zempel; S Broer; J Biber; H Murer; F Lang
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-28       Impact factor: 11.205
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