Literature DB >> 2645293

The scanning model for translation: an update.

M Kozak1.   

Abstract

The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation. The first-AUG rule is not absolute, but there are rules for breaking the rule. Some anomalous observations that seemed to contradict the scanning mechanism now appear to be artifacts. A few genuine anomalies remain unexplained.

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Year:  1989        PMID： 2645293      PMCID： PMC2115416          DOI： 10.1083/jcb.108.2.229

Source DB:  PubMed          Journal:  J Cell Biol        ISSN： 0021-9525            Impact factor:   10.539


  280 in total

1.  All foot and mouth disease virus serotypes initiate protein synthesis at two separate AUGs.

Authors:  D V Sangar; S E Newton; D J Rowlands; B E Clarke
Journal:  Nucleic Acids Res       Date:  1987-04-24       Impact factor: 16.971

2.  Stable expression of recombinant factor VIII molecules using a bovine papillomavirus vector.

Authors:  N Sarver; G A Ricca; J Link; M H Nathan; J Newman; W N Drohan
Journal:  DNA       Date:  1987-12

3.  Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain.

Authors:  D Young; K O'Neill; T Jessell; M Wigler
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

4.  Multiple upstream AUG codons mediate translational control of GCN4.

Authors:  P P Mueller; A G Hinnebusch
Journal:  Cell       Date:  1986-04-25       Impact factor: 41.582

5.  C mu-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5'-nontranslatable exon.

Authors:  G G Lennon; R P Perry
Journal:  Nature       Date:  1985 Dec 5-11       Impact factor: 49.962

6.  Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain.

Authors:  Y Ben-Neriah; A R Bauskin
Journal:  Nature       Date:  1988-06-16       Impact factor: 49.962

7.  Translational activation of the lck proto-oncogene.

Authors:  J D Marth; R W Overell; K E Meier; E G Krebs; R M Perlmutter
Journal:  Nature       Date:  1988-03-10       Impact factor: 49.962

8.  Identification of a family of muscarinic acetylcholine receptor genes.

Authors:  T I Bonner; N J Buckley; A C Young; M R Brann
Journal:  Science       Date:  1987-07-31       Impact factor: 47.728

Review 9.  Sequence and structural features associated with translational initiator regions in yeast--a review.

Authors:  A M Cigan; T F Donahue
Journal:  Gene       Date:  1987       Impact factor: 3.688

10.  Cloning and nucleotide sequence of rat ornithine decarboxylase cDNA.

Authors:  H J van Kranen; L van de Zande; C F van Kreijl; A Bisschop; B Wieringa
Journal:  Gene       Date:  1987       Impact factor: 3.688
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  1089 in total

1.  A complex translational program generates multiple novel proteins from the latently expressed kaposin (K12) locus of Kaposi's sarcoma-associated herpesvirus.

Authors:  R Sadler; L Wu; B Forghani; R Renne; W Zhong; B Herndier; D Ganem
Journal:  J Virol       Date:  1999-07       Impact factor: 5.103

2.  Non-AUG initiation of AGAMOUS mRNA translation in Arabidopsis thaliana.

Authors:  J L Riechmann; T Ito; E M Meyerowitz
Journal:  Mol Cell Biol       Date:  1999-12       Impact factor: 4.272

3.  Function of the intercistronic region of BRLF1-BZLF1 bicistronic mRNA in translating the zta protein of Epstein-Barr virus.

Authors:  P J Chang; S T Liu
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

4.  Analysis of the noncoding regions of measles virus strains in the Edmonston vaccine lineage.

Authors:  C L Parks; R A Lerch; P Walpita; H P Wang; M S Sidhu; S A Udem
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

5.  The C terminus of AvrXa10 can be replaced by the transcriptional activation domain of VP16 from the herpes simplex virus.

Authors:  W Zhu; B Yang; N Wills; L B Johnson; F F White
Journal:  Plant Cell       Date:  1999-09       Impact factor: 11.277

6.  Circular permutation and receptor insertion within green fluorescent proteins.

Authors:  G S Baird; D A Zacharias; R Y Tsien
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

7.  Internal-ribosome-entry-site functional activity of the 3'-untranslated region of the mRNA for the beta subunit of mitochondrial H+-ATP synthase.

Authors:  J M Izquierdo; J M Cuezva
Journal:  Biochem J       Date:  2000-03-15       Impact factor: 3.857

8.  Two genes required for meiotic recombination in Drosophila are expressed from a dicistronic message.

Authors:  H Liu; J K Jang; J Graham; K Nycz; K S McKim
Journal:  Genetics       Date:  2000-04       Impact factor: 4.562

9.  Expression of the ORF-2 protein of the human respiratory syncytial virus M2 gene is initiated by a ribosomal termination-dependent reinitiation mechanism.

Authors:  G Ahmadian; J S Randhawa; A J Easton
Journal:  EMBO J       Date:  2000-06-01       Impact factor: 11.598

10.  Complementarity between the mRNA 5' untranslated region and 18S ribosomal RNA can inhibit translation.

Authors:  S B Verrier; O Jean-Jean
Journal:  RNA       Date:  2000-04       Impact factor: 4.942
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