Literature DB >> 13680389

A method for the selection of production media for actinomycete strains based on their metabolite HPLC profiles.

José R Tormo1, Juan B García, Mar DeAntonio, Julia Feliz, Aurora Mira, M Teresa Díez, Pilar Hernández, Fernando Peláez.   

Abstract

The manipulation of growth conditions of microorganisms is a common strategy used by pharmaceutical companies to improve the quantities and spectra of secondary metabolites with potential therapeutic interest. In this work, the effects of fermentation media on secondary metabolite production from a set of Actinomycetes was statistically compared. For this purpose, we created an automated method for comparing the ability of microorganisms to produce different secondary metabolites. HPLC analyses guided the selection of those media in which a wider chemical diversity was obtained from microorganisms inoculated in a wide spectrum of production media. Fermented media yielding a better secondary metabolite profile were included in subsequent drug discovery screening.

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Year:  2003        PMID： 13680389     DOI： 10.1007/s10295-003-0084-7

Source DB:  PubMed          Journal:  J Ind Microbiol Biotechnol        ISSN： 1367-5435            Impact factor:   3.346


  10 in total

1.  HPLC studio: a novel software utility to perform HPLC chromatogram comparison for screening purposes.

Authors:  J B García; José R Tormo
Journal:  J Biomol Screen       Date:  2003-06

2.  Inhibition of penicillin formation by lysine.

Authors:  A L DEMAIN
Journal:  Arch Biochem Biophys       Date:  1957-03       Impact factor: 4.013

3.  Inhibitors of farnesylation of Ras from a microbial natural products screening program.

Authors:  D Vilella; M Sánchez; G Platas; O Salazar; O Genilloud; I Royo; C Cascales; I Martín; T Díez; K C Silverman; R B Lingham; S B Singh; H Jayasuriya; F Peláez
Journal:  J Ind Microbiol Biotechnol       Date:  2000-12       Impact factor: 3.346

4.  Codes and abbreviations for approved of effectively published names of genera of bacteria published from January 1980 to December 1990.

Authors:  K F Pittman; C A Walczak; C M Lock
Journal:  Int J Syst Bacteriol       Date:  1991-10

5.  Full second-order chromatographic/spectrometric data matrices for automated sample identification and component analysis by non-data-reducing image analysis.

Authors:  N P Nielsen; J Smedsgaard; J C Frisvad
Journal:  Anal Chem       Date:  1999-02-01       Impact factor: 6.986

6.  A method for quantitatively differentiating crude natural extracts using high-performance liquid chromatography-electrospray mass spectrometry.

Authors:  R K Julian; R E Higgs; J D Gygi; M D Hilton
Journal:  Anal Chem       Date:  1998-08-01       Impact factor: 6.986

7.  Implementation of conditions of the inoculum stage for Streptosporangium cultures.

Authors:  G Platas; J Collado; H Martínez; M Arrese; F Peláez; M T Díez
Journal:  Microbiologia       Date:  1997-06

Review 8.  Screening microbial metabolites for new drugs--theoretical and practical issues.

Authors:  G G Yarbrough; D P Taylor; R T Rowlands; M S Crawford; L L Lasure
Journal:  J Antibiot (Tokyo)       Date:  1993-04       Impact factor: 2.649

9.  Nutritional preferences of a group of Streptosporangium soil isolates.

Authors:  G Platas; F Peláez; J Collado; H Martínez; M T Díez
Journal:  J Biosci Bioeng       Date:  1999       Impact factor: 2.894

10.  Pneumocandins from Zalerion arboricola. II. Modification of product spectrum by mutation and medium manipulation.

Authors:  P S Masurekar; J M Fountoulakis; T C Hallada; M S Sosa; L Kaplan
Journal:  J Antibiot (Tokyo)       Date:  1992-12       Impact factor: 2.649
  10 in total
  7 in total

Review 1.  Current approaches to exploit actinomycetes as a source of novel natural products.

Authors:  Olga Genilloud; Ignacio González; Oscar Salazar; Jesus Martín; José Rubén Tormo; Francisca Vicente
Journal:  J Ind Microbiol Biotechnol       Date:  2010-10-08       Impact factor: 3.346

2.  Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi.

Authors:  Sergio Martínez-Luis; Lilia Cherigo; Sarah Higginbotham; Elizabeth Arnold; Carmenza Spadafora; Alicia Ibañez; William H Gerwick; Luis Cubilla-Rios
Journal:  Int Microbiol       Date:  2011-06       Impact factor: 2.479

3.  Assessing the effects of adsorptive polymeric resin additions on fungal secondary metabolite chemical diversity.

Authors:  Víctor González-Menéndez; Francisco Asensio; Catalina Moreno; Nuria de Pedro; Maria Candida Monteiro; Mercedes de la Cruz; Francisca Vicente; Gerald F Bills; Fernando Reyes; Olga Genilloud; José R Tormo
Journal:  Mycology       Date:  2014-07-22

4.  Production of Ramoplanin and Ramoplanin Analogs by Actinomycetes.

Authors:  Mercedes de la Cruz; Ignacio González; Craig A Parish; Russell Onishi; José R Tormo; Jesús Martín; Fernando Peláez; Debbie Zink; Noureddine El Aouad; Fernando Reyes; Olga Genilloud; Francisca Vicente
Journal:  Front Microbiol       Date:  2017-03-06       Impact factor: 5.640

5.  A rapid screening method for the detection of specialised metabolites from bacteria: Induction and suppression of metabolites from Burkholderia species.

Authors:  Gordon Webster; Cerith Jones; Alex J Mullins; Eshwar Mahenthiralingam
Journal:  J Microbiol Methods       Date:  2020-09-14       Impact factor: 2.363

6.  Kribbellichelins A and B, Two New Antibiotics from Kribbella sp. CA-293567 with Activity against Several Human Pathogens.

Authors:  Jorge R Virués-Segovia; Fernando Reyes; Sandra Ruíz; Jesús Martín; Ignacio Fernández-Pastor; Carlos Justicia; Mercedes de la Cruz; Caridad Díaz; Thomas A Mackenzie; Olga Genilloud; Ignacio González; José R Tormo
Journal:  Molecules       Date:  2022-09-26       Impact factor: 4.927

7.  Production of hydroxy marilone C as a bioactive compound fromStreptomyces badius.

Authors:  Osama H El Sayed; Mohsen M S Asker; Mahmoud A Swelim; Ibrahim H Abbas; Aziza I Attwa; Mohamed E El Awady
Journal:  J Genet Eng Biotechnol       Date:  2016-05-12
  7 in total

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