Literature DB >> 13679996

BRCA1 and p53: compensatory roles in DNA repair.

Anne-Renee Hartman1, James M Ford.   

Abstract

The BRCA1 breast cancer susceptibility gene has been implicated in many cellular processes, yet its specific mechanism of tumor suppression remains unclear. BRCA1 plays a role in several DNA repair pathways including nucleotide excision repair (NER). Loss of the p53 tumor suppressor gene, a key regulator of NER, is an important and necessary event in the pathogenesis of BRCA1-mutated tumors. Here we discuss the role of BRCA1 and NER in breast cancer and the interactions of BRCA1 with p53 in breast tumorigenesis and suggest approaches for risk assessment and chemotherapeutic management of BRCA1-related breast cancer.

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Year:  2003        PMID： 13679996     DOI： 10.1007/s00109-003-0477-0

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


  77 in total

1.  BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression.

Authors:  T K MacLachlan; K Somasundaram; M Sgagias; Y Shifman; R J Muschel; K H Cowan; W S El-Deiry
Journal:  J Biol Chem       Date:  2000-01-28       Impact factor: 5.157

2.  p53 responsive nucleotide excision repair gene products p48 and XPC, but not p53, localize to sites of UV-irradiation-induced DNA damage, in vivo.

Authors:  Maureen E Fitch; Irina V Cross; James M Ford
Journal:  Carcinogenesis       Date:  2003-05       Impact factor: 4.944

3.  Genetic analysis of BRCA1 function in a defined tumor cell line.

Authors:  R Scully; S Ganesan; K Vlasakova; J Chen; M Socolovsky; D M Livingston
Journal:  Mol Cell       Date:  1999-12       Impact factor: 17.970

4.  BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene.

Authors:  J N Snouwaert; L C Gowen; A M Latour; A R Mohn; A Xiao; L DiBiase; B H Koller
Journal:  Oncogene       Date:  1999-12-20       Impact factor: 9.867

5.  Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity.

Authors:  H Ruffner; C A Joazeiro; D Hemmati; T Hunter; I M Verma
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-24       Impact factor: 11.205

Review 6.  Role of DNA excision repair gene defects in the etiology of cancer.

Authors:  J M Ford; P C Hanawalt
Journal:  Curr Top Microbiol Immunol       Date:  1997       Impact factor: 4.291

7.  Loss of heterozygosity of nucleotide excision repair factors in sporadic ovarian, colon and lung carcinomas: implication for their roles of carcinogenesis in human solid tumors.

Authors:  Y Takebayashi; K Nakayama; A Kanzaki; H Miyashita; O Ogura; S Mori; M Mutoh; K Miyazaki; M Fukumoto; Y Pommier
Journal:  Cancer Lett       Date:  2001-12-28       Impact factor: 8.679

8.  Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.

Authors:  D Cortez; Y Wang; J Qin; S J Elledge
Journal:  Science       Date:  1999-11-05       Impact factor: 47.728

9.  Familial invasive breast cancers: worse outcome related to BRCA1 mutations.

Authors:  D Stoppa-Lyonnet; Y Ansquer; H Dreyfus; C Gautier; M Gauthier-Villars; E Bourstyn; K B Clough; H Magdelénat; P Pouillart; A Vincent-Salomon; A Fourquet; B Asselain
Journal:  J Clin Oncol       Date:  2000-12-15       Impact factor: 44.544

10.  p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene.

Authors:  Shanthi Adimoolam; James M Ford
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-19       Impact factor: 11.205
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  18 in total

1.  "Similarity trap" in protein-protein interactions could be carcinogenic: simulations of p53 core domain complexed with 53BP1 and BRCA1 BRCT domains.

Authors:  Jin Liu; Yongping Pan; Buyong Ma; Ruth Nussinov
Journal:  Structure       Date:  2006-12       Impact factor: 5.006

2.  Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance.

Authors:  Anna L Seager; Ume-Kulsoom Shah; Jane M Mikhail; Bryant C Nelson; Bryce J Marquis; Shareen H Doak; George E Johnson; Sioned M Griffiths; Paul L Carmichael; Sharon J Scott; Andrew D Scott; Gareth J S Jenkins
Journal:  Toxicol Sci       Date:  2012-04-26       Impact factor: 4.849

3.  Clinical implications for BRCA gene mutation in breast cancer.

Authors:  Jin Xu; Baosheng Wang; Yanjun Zhang; Ruihui Li; Yuehua Wang; Shaokun Zhang
Journal:  Mol Biol Rep       Date:  2011-06-21       Impact factor: 2.316

4.  The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice.

Authors:  Xiao Zhen Zhou; Pengyu Huang; Rong Shi; Tae Ho Lee; Gina Lu; Zhihong Zhang; Roderick Bronson; Kun Ping Lu
Journal:  J Clin Invest       Date:  2011-03-23       Impact factor: 14.808

Review 5.  Treatment options for patients with triple-negative breast cancer.

Authors:  Rafael Santana-Davila; Edith A Perez
Journal:  J Hematol Oncol       Date:  2010-10-27       Impact factor: 17.388

6.  Defective repair of oxidative dna damage in triple-negative breast cancer confers sensitivity to inhibition of poly(ADP-ribose) polymerase.

Authors:  Elizabeth Alli; Vandana B Sharma; Preethi Sunderesakumar; James M Ford
Journal:  Cancer Res       Date:  2009-04-07       Impact factor: 12.701

7.  BRCA1 can modulate RNA polymerase II carboxy-terminal domain phosphorylation levels.

Authors:  Annie Moisan; Chantal Larochelle; Benoît Guillemette; Luc Gaudreau
Journal:  Mol Cell Biol       Date:  2004-08       Impact factor: 4.272

8.  Xeroderma pigmentosum complementation group C genotypes/diplotypes play no independent or interaction role with polycyclic aromatic hydrocarbons-DNA adducts for breast cancer risk.

Authors:  Jing Shen; Marilie D Gammon; Mary Beth Terry; Susan L Teitelbaum; Sybil M Eng; Alfred I Neugut; Regina M Santella
Journal:  Eur J Cancer       Date:  2007-11-28       Impact factor: 9.162

9.  The role of hypoxia in 2-butoxyethanol-induced hemangiosarcoma.

Authors:  Daphna Laifenfeld; Annalyn Gilchrist; David Drubin; Milena Jorge; Sean F Eddy; Brian P Frushour; Bill Ladd; Leslie A Obert; Mark M Gosink; Jon C Cook; Kay Criswell; Christopher J Somps; Petra Koza-Taylor; Keith O Elliston; Michael P Lawton
Journal:  Toxicol Sci       Date:  2009-10-07       Impact factor: 4.849

10.  Therapeutic targeting of BRCA1-mutated breast cancers with agents that activate DNA repair.

Authors:  Elizabeth Alli; David Solow-Cordero; Stephanie C Casey; James M Ford
Journal:  Cancer Res       Date:  2014-09-12       Impact factor: 12.701
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