| Literature DB >> 10635334 |
R Scully1, S Ganesan, K Vlasakova, J Chen, M Socolovsky, D M Livingston.
Abstract
Retrovirally expressed, wild-type BRCA1 decreased the gamma radiation (IR) sensitivity and increased the efficiency of double-strand DNA break repair (DSBR) of the BRCA1-/- human breast cancer line, HCC1937. It also reduced its susceptibility to DSB generation by IR. By contrast, multiple, clinically validated, missense mutant BRCA1 products were nonfunctional in these assays. These data constitute the basis for a BRCA1 functional assay and suggest that efficient repair of double-strand DNA breaks is linked to BRCA1 tumor suppression function.Entities:
Mesh：
Substances：
Year: 1999 PMID： 10635334 DOI： 10.1016/s1097-2765(00)80238-5
Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970