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Literature DB >> 13651571

2-Hydroxyiminomethyl-N-methylpyridinium methanesulphonate and atropine in the treatment of severe organophosphate poisoning.

Abstract

The soluble methanesulphonate of the oxime 2-hydroxyiminomethyl-N-methylpyridinium (P2S) has been used to treat animals poisoned with sarin or ethyl pyrophosphate. The effect of the size of the dose, and its time of administration in relation to poisoning, have been examined. This oxime is very efficient in conjunction with atropine when given either before or after poisoning. About 30 mg./kg. seems to be the optimum therapeutic dose of the methanesulphonate. The significance of this optimum is discussed in relation to the treatment of accidental poisoning by organophosphate insecticides in man.

Entities: Chemical Disease Species

Keywords: PHOSPHATES/poisoning; PYRANS/therapeutic use

Mesh：

Substances：

Year: 1959 PMID： 13651571 PMCID： PMC1481822 DOI： 10.1111/j.1476-5381.1959.tb00920.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

10 in total

1. [Antidotal action of alpha-pyridylaldoxime iodomethylate toward experimental poisoning induced by organic phosphate insecticides].

Authors: J FOURNEL
Journal: C R Seances Soc Biol Fil Date: 1957

7. USE OF MOVING AVERAGES AND INTERPOLATION TO ESTIMATE MEDIAN-EFFECTIVE DOSE: I. Fundamental Formulas, Estimation of Error, and Relation to Other Methods.

Authors: W R Thompson
Journal: Bacteriol Rev Date: 1947-06

5 in total

2-Hydroxyiminomethyl-N-methylpyridinium methanesulphonate and atropine in the treatment of severe organophosphate poisoning.

1. [Antidotal action of alpha-pyridylaldoxime iodomethylate toward experimental poisoning induced by organic phosphate insecticides].

2. A specific antidote against lethal alkyl phosphate intoxication. V. Antidotal properties.

3. Pyridine-2-aldoxime methiodide and poisoning by anticholinesterases.

4. The toxicity of 2-hydroxyiminomethyl-N-methylpyridinium methanesulphonate (P2S).

5. PAM (pyridine-2-aldoxime methiodide) therapy for alkyl-phosphate poisoning.

6. A specific antidote against lethal alkyl phosphate intoxication. II. Antidotal properties.

7. USE OF MOVING AVERAGES AND INTERPOLATION TO ESTIMATE MEDIAN-EFFECTIVE DOSE: I. Fundamental Formulas, Estimation of Error, and Relation to Other Methods.

8. The reactivation of cholinesterase inhibited with organophosphorus compounds. I. Reactivation by 2-oxoaldoximes.

9. Protection against the lethal effects of organophosphates by pyridine-2-aldoxime methiodide.

10. Oximes and atropine in sarin poisoning.

1. Plasma concentrations of the oxime Pralidoxime Mesylate (P2S) after repeated oral and intramuscular administration.

2. Therapeutic effects of HS-3, HS-6, benactyzine, and atropine in soman poisoning of dogs.

3. On a successfully treated acute oral paraoxone (E 600) poisoning.

4. The protective actions of some anticholinergic drugs in sarin poisoning.

5. Quantitative studies of the effect of antagonists on the acute toxicity of organophosphates in rats.