Literature DB >> 13536287

The toxicity of 2-hydroxyiminomethyl-N-methylpyridinium methanesulphonate (P2S).

D R DAVIES, G L WILLEY.   

Abstract

The toxicity of 2-hydroxyiminomethyl-N-methylpyridinium methanesulphonate (P2S) has been determined in a number of species by various routes. It is approximately equally toxic in the rat, mouse, and guinea-pig. It is much more toxic in the dog. Atropine influences the toxicity of P2S differently in different species. From the results obtained attempts have been made to assess the maximum safe dose which can be given intramuscularly to man.

Entities:  

Keywords:  PYRIDINES/toxicity

Mesh：

Substances：

Year:  1958        PMID： 13536287      PMCID： PMC1481720          DOI： 10.1111/j.1476-5381.1958.tb00218.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  6 in total

1.  Pyridine-2-aldoxime methiodide and poisoning by anticholinesterases.

Authors:  J H WILLS; A M KUNKEL; R V BROWN; G E GROBLEWSKI
Journal:  Science       Date:  1957-04-19       Impact factor: 47.728

2.  Studies on a group of oximes as therapeutic compounds in sarin poisoning.

Authors:  L DULTZ; M A EPSTEIN; G FREEMAN; E H GRAY; W B WEIL
Journal:  J Pharmacol Exp Ther       Date:  1957-04       Impact factor: 4.030

3.  A specific antidote against lethal alkyl phosphate intoxication. II. Antidotal properties.

Authors:  H KEWITZ; D NACHMANSOHN; I B WILSON
Journal:  Arch Biochem Biophys       Date:  1956-10       Impact factor: 4.013

4.  The nature of the toxicity of 2-oxo-oximes.

Authors:  B M ASKEW; D R DAVIES; A L GREEN; R HOLMES
Journal:  Br J Pharmacol Chemother       Date:  1956-12

5.  A specific antidote against lethal alkylphosphate intoxication.

Authors:  H KEWITZ; I B WILSON
Journal:  Arch Biochem Biophys       Date:  1956-01       Impact factor: 4.013

6.  USE OF MOVING AVERAGES AND INTERPOLATION TO ESTIMATE MEDIAN-EFFECTIVE DOSE: I. Fundamental Formulas, Estimation of Error, and Relation to Other Methods.

Authors:  W R Thompson
Journal:  Bacteriol Rev       Date:  1947-06
  6 in total
  3 in total

1.  THE TOXICITY OF SOME CHOLINESTERASE REACTIVATING OXIMES.

Authors:  L ALBANUS; B JAERPLID; A SUNDWALL
Journal:  Br J Exp Pathol       Date:  1964-04

2.  2-Hydroxyiminomethyl-N-methylpyridinium methanesulphonate and atropine in the treatment of severe organophosphate poisoning.

Authors:  D R DAVIES; A L GREEN; G L WILLEY
Journal:  Br J Pharmacol Chemother       Date:  1959-03

3.  The effects of intracisternal sarin and pyridine-2-aldoxime methyl methanesulphonate in anesthetized dogs.

Authors:  R V BROWN
Journal:  Br J Pharmacol Chemother       Date:  1960-03
  3 in total

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