Literature DB >> 1351866

Nonrandom association between Huntington disease and two loci separated by about 3 Mb on 4p16.3.

S Andrew1, J Theilmann, A Hedrick, D Mah, B Weber, M R Hayden.   

Abstract

The gene for Huntington disease (HD) has been localized close to the telomere on the short arm of chromosome 4. However, refined mapping using recombinant HD chromosomes has resulted in conflicting findings and mutually exclusive candidate regions. Previously reported significant nonrandom allelic association between D4S95 and HD provided support for a more proximal location for the defective gene. In this paper, we have analyzed 17 markers, spanning approximately 6 Mb of DNA distal to locus D4S62, for nonrandom association to HD. We confirm the previous findings of nonrandom allelic association between D4S95 and HD. In addition, we provide new data showing significant nonrandom association between HD and 3 markers at D4S133 and D4S228, which are approximately 3 Mb telomeric to D4S95.

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Year:  1992        PMID： 1351866     DOI： 10.1016/0888-7543(92)90246-o

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  11 in total

1.  Predicting the range of linkage disequilibrium.

Authors:  J Ott
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-04       Impact factor: 11.205

2.  Allelic association under map error and recombinational heterogeneity: a tale of two sites.

Authors:  C Lonjou; A Collins; R S Ajioka; L B Jorde; J P Kushner; N E Morton
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-15       Impact factor: 11.205

3.  Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers.

Authors:  K A Goddard; C E Yu; J Oshima; T Miki; J Nakura; C Piussan; G M Martin; G D Schellenberg; E M Wijsman
Journal:  Am J Hum Genet       Date:  1996-06       Impact factor: 11.025

4.  Linkage disequilibrium and extended haplotypes in the HLA-A to D6S105 region: implications for mapping the hemochromatosis gene (HFE).

Authors:  G Gandon; A M Jouanolle; B Chauvel; V Mauvieux; A le Treut; J Feingold; J Y Le Gall; V David; J Yaouanq
Journal:  Hum Genet       Date:  1996-01       Impact factor: 4.132

5.  Likelihood methods for locating disease genes in nonequilibrium populations.

Authors:  N L Kaplan; W G Hill; B S Weir
Journal:  Am J Hum Genet       Date:  1995-01       Impact factor: 11.025

6.  Geographical distribution of haplotypes in Swedish families with Huntington's disease.

Authors:  E Almqvist; S Andrew; J Theilmann; P Goldberg; J Zeisler; U Drugge; U Grandell; M Tapper-Persson; B Winblad; M Hayden
Journal:  Hum Genet       Date:  1994-08       Impact factor: 4.132

7.  Anonymous marker loci within 400 kb of HLA-A generate haplotypes in linkage disequilibrium with the hemochromatosis gene (HFE)

Authors:  J Yaouanq; M Perichon; M Chorney; P Pontarotti; A Le Treut; A el Kahloun; V Mauvieux; M Blayau; A M Jouanolle; B Chauvel
Journal:  Am J Hum Genet       Date:  1994-02       Impact factor: 11.025

8.  Huntington disease without CAG expansion: phenocopies or errors in assignment?

Authors:  S E Andrew; Y P Goldberg; B Kremer; F Squitieri; J Theilmann; J Zeisler; H Telenius; S Adam; E Almquist; M Anvret
Journal:  Am J Hum Genet       Date:  1994-05       Impact factor: 11.025

9.  Significant linkage disequilibrium between the Huntington's disease locus and markers at loci D4S10, D4S95, and D4S111 in Northern Ireland.

Authors:  P J Morrison; C A Graham; N C Nevin
Journal:  J Med Genet       Date:  1993-12       Impact factor: 6.318

10.  Allele frequencies and linkage disequilibrium of polymorphic DNA markers of the Huntington disease region in the German population.

Authors:  U Thies; B Bockel; B Gerdes; K Schröder
Journal:  Hum Genet       Date:  1993-12       Impact factor: 4.132
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