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Literature DB >> 1348495

Alleles of the rat T-cell receptor beta chain gene complex.

E P Blankenhorn¹, P D Smith, C B Williams, G A Gutman.

Abstract

Inbred rat strains provide a rich source of genetic diversity in immunologically relevant genes. We have characterized the alleles of one of these genes, encoding the rat T-cell receptor C beta 1 chain, by Southern blots and nucleic acid sequencing. The Cb1 gene segments from DA and LEW rats display complex allotypic variation: both coding and noncoding regions contain multiple nucleotide substitutions. In addition, there is a polymorphic insertion of a rat repetitive LINE element 3' to the coding region. The Cb1 alleles are one part of larger Tcrb haplotypes, containing V beta, D beta, and J beta elements; complete Cb1 genomic nucleotide sequences, and a partial list of the strain distribution of the two alleles, are described in this report.

Entities: Gene Species

Mesh：

Substances：

Year: 1992 PMID： 1348495 DOI： 10.1007/bf00189895

Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846

23 in total

1. Orientation of the loci encoding RT1.B polypeptides in the major histocompatibility complex of the rat.

Authors: E P Blankenhorn; D V Cramer
Journal: Immunogenetics Date: 1985 Impact factor: 2.846

2. T-cell receptor V alpha and C alpha alleles associated with multiple and myasthenia gravis.

Authors: J R Oksenberg; M Sherritt; A B Begovich; H A Erlich; C C Bernard; L L Cavalli-Sforza; L Steinman
Journal: Proc Natl Acad Sci U S A Date: 1989-02 Impact factor: 11.205

3. T cell receptor beta chain usage in myelin basic protein-specific rat T lymphocytes.

Authors: J Chluba; C Steeg; A Becker; H Wekerle; J T Epplen
Journal: Eur J Immunol Date: 1989-02 Impact factor: 5.532

4. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors: A P Feinberg; B Vogelstein
Journal: Anal Biochem Date: 1983-07-01 Impact factor: 3.365

5. Insertion of long interspersed repeated elements at the Igh (immunoglobulin heavy chain) and Mlvi-2 (Moloney leukemia virus integration 2) loci of rats.

Authors: A Economou-Pachnis; M A Lohse; A V Furano; P N Tsichlis
Journal: Proc Natl Acad Sci U S A Date: 1985-05 Impact factor: 11.205

6. Genetic differences in the T cell receptor alleles of LEW rats and their encephalomyelitis-resistant derivative, LER, and their impact on the inheritance of EAE resistance.

Authors: E P Blankenhorn; S A Stranford; P D Smith; W F Hickey
Journal: Eur J Immunol Date: 1991-09 Impact factor: 5.532

7. Thyroglobulin antibodies in Graves' disease are associated with T-cell receptor beta chain and major histocompatibility complex loci.

Authors: A G Demaine; S Ratanachaiyavong; R Pope; D Ewins; B A Millward; A M McGregor
Journal: Clin Exp Immunol Date: 1989-07 Impact factor: 4.330

8. Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide.

Authors: M Malissen; K Minard; S Mjolsness; M Kronenberg; J Goverman; T Hunkapiller; M B Prystowsky; Y Yoshikai; F Fitch; T W Mak
Journal: Cell Date: 1984-07 Impact factor: 41.582

Alleles of the rat T-cell receptor beta chain gene complex.

1. Orientation of the loci encoding RT1.B polypeptides in the major histocompatibility complex of the rat.

2. T-cell receptor V alpha and C alpha alleles associated with multiple and myasthenia gravis.

3. T cell receptor beta chain usage in myelin basic protein-specific rat T lymphocytes.

4. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

5. Insertion of long interspersed repeated elements at the Igh (immunoglobulin heavy chain) and Mlvi-2 (Moloney leukemia virus integration 2) loci of rats.

6. Genetic differences in the T cell receptor alleles of LEW rats and their encephalomyelitis-resistant derivative, LER, and their impact on the inheritance of EAE resistance.

7. Thyroglobulin antibodies in Graves' disease are associated with T-cell receptor beta chain and major histocompatibility complex loci.

8. Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide.

9. DNA sequencing with chain-terminating inhibitors.

10. Organization and nucleotide sequence of the rat T cell receptor beta-chain complex.

1. Sequence and diversity of rat T-cell receptor alpha-chain-encoding genes.

2. Genetic map of 16 polymorphic markers forming three linkage groups assigned to rat chromosome 4.

3. New nucleotide sequence data on the EMBL File Server.