Literature DB >> 2571937

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16.

S Stern1, M Tanaka, W Herr.   

Abstract

The herpes simplex virus transactivator VP16 participates in the formation of a multiprotein-DNA complex with the ubiquitous octamer-motif-binding factor Oct-1. Complex formation is dependent on specific amino acids in the Oct-1 homoeodomain which are in positions analogous to positive control mutations in helix 2 of the lambda phage repressor helix-turn-helix motif, indicating that this structure is an ancient target for protein-protein interactions mediating transcriptional control.

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Year:  1989        PMID： 2571937     DOI： 10.1038/341624a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  193 in total

1.  Autostimulation of the Epstein-Barr virus BRLF1 promoter is mediated through consensus Sp1 and Sp3 binding sites.

Authors:  T Ragoczy; G Miller
Journal:  J Virol       Date:  2001-06       Impact factor: 5.103

Review 2.  HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part I. HSV-1 structure, replication and pathogenesis.

Authors:  A Jacobs; X O Breakefield; C Fraefel
Journal:  Neoplasia       Date:  1999-11       Impact factor: 5.715

3.  Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor.

Authors:  R Lu; P Yang; P O'Hare; V Misra
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

4.  Differences in determinants required for complex formation and transactivation in related VP16 proteins.

Authors:  M Grapes; P O'Hare
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

5.  Histone H2B gene transcription during Xenopus early development requires functional cooperation between proteins bound to the CCAAT and octamer motifs.

Authors:  C Hinkley; M Perry
Journal:  Mol Cell Biol       Date:  1992-10       Impact factor: 4.272

6.  The Oct-1 POU domain mediates interactions between Oct-1 and other POU proteins.

Authors:  C P Verrijzer; J A van Oosterhout; P C van der Vliet
Journal:  Mol Cell Biol       Date:  1992-02       Impact factor: 4.272

7.  Oct-1 is posttranslationally modified and exhibits reduced capacity to bind cognate sites at late times after infection with herpes simplex virus 1.

Authors:  Sunil J Advani; Lizette O Durand; Ralph R Weichselbaum; Bernard Roizman
Journal:  J Virol       Date:  2003-11       Impact factor: 5.103

8.  An indirect negative autoregulatory mechanism involved in hepatocyte nuclear factor-1 gene expression.

Authors:  A A Kritis; E Ktistaki; D Barda; V I Zannis; I Talianidis
Journal:  Nucleic Acids Res       Date:  1993-12-25       Impact factor: 16.971

9.  Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer.

Authors:  L Dailey; H Yuan; C Basilico
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

10.  Targeting of promoters for trans activation by a carboxy-terminal domain of the NS-1 protein of the parvovirus minute virus of mice.

Authors:  D Legendre; J Rommelaere
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103
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