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Literature DB >> 1335571

A cyclic AMP response element is involved in retinoic acid-dependent RAR beta 2 promoter activation.

F A Kruyt¹, G Folkers, C E van den Brink, P T van der Saag.

Abstract

Activation of the retinoic acid receptor (RAR) beta 2 promoter is known to be mediated by a RA response element located in the proximity of the TATA-box. By deletion studies in P19 embryonal carcinoma cells we have analyzed the RAR beta 2 promoter for the presence of additional regulatory elements. We found that the cyclic AMP response element-related motif, TGATGTCA at position -99 to -92, is able to enhance RA-dependent RAR beta 2 promoter activation. In addition we demonstrate that this element, designated CRE-beta 2, is functionally active as a CRE since it can bind members of the CREB/ATF transcription factor family and, moreover, mediates the stimulatory effect of cAMP on RA-dependent RAR beta 2 promoter activation in human foetal kidney 293 cells.

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Year: 1992 PMID： 1335571 PMCID： PMC334532 DOI： 10.1093/nar/20.23.6393

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

63 in total

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