Literature DB >> 1335449

Cyclooctatin, a new inhibitor of lysophospholipase, produced by Streptomyces melanosporofaciens MI614-43F2. Taxonomy, production, isolation, physico-chemical properties and biological activities.

T Aoyagi1, T Aoyama, F Kojima, S Hattori, Y Honma, M Hamada, T Takeuchi.   

Abstract

Cyclooctatin has been isolated from Streptomyces melanosporofaciens MI614-43F2 as part of a program designed to find microorganism-produced inhibitors of lysophospholipase. It was purified by chromatography on silica gel, Capcell Pak C18 (HPLC) and Sephadex LH-20 followed by solvent extraction and then isolated as a colorless powder. Cyclooctatin has the molecular formula of C20H34O3. It is competitive with the substrate, and the inhibition constant (Ki) was 4.8 x 10(-6) M.

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Year:  1992        PMID： 1335449     DOI： 10.7164/antibiotics.45.1587

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  9 in total

Review 1.  Structural and Chemical Biology of Terpenoid Cyclases.

Authors:  David W Christianson
Journal:  Chem Rev       Date:  2017-08-25       Impact factor: 60.622

2.  17-Hydroxycyclooctatin, a fused 5-8-5 ring diterpene, from Streptomyces sp. MTE4a.

Authors:  Akira Kawamura; Maria Iacovidou; Emiri Hirokawa; Clifford E Soll; Monica Trujillo
Journal:  J Nat Prod       Date:  2011-02-11       Impact factor: 4.050

Review 3.  Bacterial terpenome.

Authors:  Jeffrey D Rudolf; Tyler A Alsup; Baofu Xu; Zining Li
Journal:  Nat Prod Rep       Date:  2021-05-26       Impact factor: 15.111

Review 4.  Recent highlights in biosynthesis research using stable isotopes.

Authors:  Jan Rinkel; Jeroen S Dickschat
Journal:  Beilstein J Org Chem       Date:  2015-12-09       Impact factor: 2.883

5.  Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis.

Authors:  Ronja Driller; Sophie Janke; Monika Fuchs; Evelyn Warner; Anil R Mhashal; Dan Thomas Major; Mathias Christmann; Thomas Brück; Bernhard Loll
Journal:  Nat Commun       Date:  2018-09-28       Impact factor: 14.919

6.  Phylogenomic analyses and distribution of terpene synthases among Streptomyces.

Authors:  Lara Martín-Sánchez; Kumar Saurabh Singh; Mariana Avalos; Gilles P van Wezel; Jeroen S Dickschat; Paolina Garbeva
Journal:  Beilstein J Org Chem       Date:  2019-05-29       Impact factor: 2.883

7.  Modular access to functionalized 5-8-5 fused ring systems via a photoinduced cycloisomerization reaction.

Authors:  Anna E Salvati; James A Law; Josue Liriano; James H Frederich
Journal:  Chem Sci       Date:  2018-05-25       Impact factor: 9.825

Review 8.  Current understanding and biotechnological application of the bacterial diterpene synthase CotB2.

Authors:  Ronja Driller; Daniel Garbe; Norbert Mehlmer; Monika Fuchs; Keren Raz; Dan Thomas Major; Thomas Brück; Bernhard Loll
Journal:  Beilstein J Org Chem       Date:  2019-10-02       Impact factor: 2.883

Review 9.  Diterpenes Specially Produced by Fungi: Structures, Biological Activities, and Biosynthesis (2010-2020).

Authors:  Fa-Lei Zhang; Tao Feng
Journal:  J Fungi (Basel)       Date:  2022-02-28
  9 in total

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