Literature DB >> 1320631

Identification of hepatitis C viruses with a nonconserved sequence of the 5' untranslated region.

C H Lee1, C Cheng, J Wang, L Lumeng.   

Abstract

The nucleotide sequence of the 5' untranslated region of hepatitis C virus (HCV) has been shown to be conserved. In contrast, we have detected more sequence variation in this region in several HCV isolates than hitherto expected. The nucleotide sequences of the 5' untranslated regions of these isolates differ significantly from that of the prototype but are very similar to each other. We believe that these isolates belong to the same type of HCV. Among 240 HCV RNA polymerase chain reaction-positive specimens that we examined, 7 belong to this type. The results suggest that the HCV variants that we detected represent a different type of HCV and that they are responsible for approximately 3% of HCV infections in patients that we have examined.

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Year:  1992        PMID： 1320631      PMCID： PMC265342          DOI： 10.1128/jcm.30.6.1602-1604.1992

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  21 in total

1.  Nucleotide sequence of core and envelope genes of the hepatitis C virus genome derived directly from human healthy carriers.

Authors:  K Takeuchi; Y Kubo; S Boonmar; Y Watanabe; T Katayama; Q L Choo; G Kuo; M Houghton; I Saito; T Miyamura
Journal:  Nucleic Acids Res       Date:  1990-08-11       Impact factor: 16.971

2.  Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome.

Authors:  Q L Choo; G Kuo; A J Weiner; L R Overby; D W Bradley; M Houghton
Journal:  Science       Date:  1989-04-21       Impact factor: 47.728

Review 3.  Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease.

Authors:  M Houghton; A Weiner; J Han; G Kuo; Q L Choo
Journal:  Hepatology       Date:  1991-08       Impact factor: 17.425

4.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

Authors:  P Chomczynski; N Sacchi
Journal:  Anal Biochem       Date:  1987-04       Impact factor: 3.365

Review 5.  Hepatitis C virus: the major causative agent of viral non-A, non-B hepatitis.

Authors:  Q L Choo; A J Weiner; L R Overby; G Kuo; M Houghton; D W Bradley
Journal:  Br Med Bull       Date:  1990-04       Impact factor: 4.291

6.  The 5'-terminal sequence of the hepatitis C virus genome.

Authors:  H Okamoto; S Okada; Y Sugiyama; S Yotsumoto; T Tanaka; H Yoshizawa; F Tsuda; Y Miyakawa; M Mayumi
Journal:  Jpn J Exp Med       Date:  1990-06

7.  Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups.

Authors:  R H Miller; R H Purcell
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

8.  Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly(A) tails at the 3' end.

Authors:  J H Han; V Shyamala; K H Richman; M J Brauer; B Irvine; M S Urdea; P Tekamp-Olson; G Kuo; Q L Choo; M Houghton
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-01       Impact factor: 11.205

9.  Genetic organization and diversity of the hepatitis C virus.

Authors:  Q L Choo; K H Richman; J H Han; K Berger; C Lee; C Dong; C Gallegos; D Coit; R Medina-Selby; P J Barr
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

10.  An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis.

Authors:  G Kuo; Q L Choo; H J Alter; G L Gitnick; A G Redeker; R H Purcell; T Miyamura; J L Dienstag; M J Alter; C E Stevens
Journal:  Science       Date:  1989-04-21       Impact factor: 47.728
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  9 in total

1.  Hepatitis C virus does not cause nonalcoholic steatohepatitis.

Authors:  D W Rogers; C H Lee; D C Pound; S Kumar; O W Cummings; L Lumeng
Journal:  Dig Dis Sci       Date:  1992-11       Impact factor: 3.199

2.  Novel, ligation-dependent PCR assay for detection of hepatitis C in serum.

Authors:  T C Hsuih; Y N Park; C Zaretsky; F Wu; S Tyagi; F R Kramer; R Sperling; D Y Zhang
Journal:  J Clin Microbiol       Date:  1996-03       Impact factor: 5.948

3.  IMP dehydrogenase from Pneumocystis carinii as a potential drug target.

Authors:  M J O'Gara; C H Lee; G A Weinberg; J M Nott; S F Queener
Journal:  Antimicrob Agents Chemother       Date:  1997-01       Impact factor: 5.191

4.  At least 12 genotypes of hepatitis C virus predicted by sequence analysis of the putative E1 gene of isolates collected worldwide.

Authors:  J Bukh; R H Purcell; R H Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-01       Impact factor: 11.205

5.  Sequence analysis of the 5' untranslated region in isolates of at least four genotypes of hepatitis C virus in The Netherlands.

Authors:  G E Kleter; L J van Doorn; J T Brouwer; S W Schalm; R A Heijtink; W G Quint
Journal:  J Clin Microbiol       Date:  1994-02       Impact factor: 5.948

Review 6.  Hepatitis C: progress and problems.

Authors:  J A Cuthbert
Journal:  Clin Microbiol Rev       Date:  1994-10       Impact factor: 26.132

7.  Presence of hepatitis C virus (HCV) genomic RNA and viral replicative intermediates in bone marrow and peripheral blood mononuclear cells from HCV-infected patients.

Authors:  A Manzin; M Candela; S Paolucci; M L Caniglia; A Gabrielli; M Clementi
Journal:  Clin Diagn Lab Immunol       Date:  1994-03

Review 8.  Virology of hepatitis C virus.

Authors:  P Simmonds
Journal:  Clin Ther       Date:  1996       Impact factor: 3.393

Review 9.  Variability of hepatitis C virus.

Authors:  P Simmonds
Journal:  Hepatology       Date:  1995-02       Impact factor: 17.425
  9 in total

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