Literature DB >> 1329725

Cell shrinkage follows, rather than mediates, the short-term effects of glucagon on carbohydrate metabolism.

V Gaussin1, A Baquet, L Hue.   

Abstract

The initial effects of glucagon on glycogen breakdown in isolated hepatocytes were found to be independent of cell volume and, when it occurred, cell shrinkage followed rather than mediated the glycogenolytic effect of glucagon. Similar conclusions could be drawn for the effect of glucagon on glycolysis/gluconeogenesis and for the antagonistic effect of insulin on glucagon action.

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Year:  1992        PMID： 1329725      PMCID： PMC1133117          DOI： 10.1042/bj2870017

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  23 in total

1.  A method using 3-O-methyl-D-glucose and phloretin for the determination of intracellular water space of cells in monolayer culture.

Authors:  R F Kletzien; M W Pariza; J E Becker; V R Potter
Journal:  Anal Biochem       Date:  1975-10       Impact factor: 3.365

2.  The role of cell swelling in the stimulation of glycogen synthesis by insulin.

Authors:  M al-Habori; M Peak; T H Thomas; L Agius
Journal:  Biochem J       Date:  1992-03-15       Impact factor: 3.857

Review 3.  Cell volume in the regulation of hepatic function: a mechanism for metabolic control.

Authors:  D Häussinger; F Lang
Journal:  Biochim Biophys Acta       Date:  1991-12-12

4.  Regulation in vitro and in vivo of adenosine 3':5'-monophosphate-dependent inactivation of rat-liver pyruvate kinase type L.

Authors:  J E Felíu; L Hue; H G Hers
Journal:  Eur J Biochem       Date:  1977-12

5.  Regulation of glycogen synthesis and glycolysis by insulin, pH and cell volume. Interactions between swelling and alkalinization in mediating the effects of insulin.

Authors:  M Peak; M al-Habori; L Agius
Journal:  Biochem J       Date:  1992-03-15       Impact factor: 3.857

6.  Hepatocyte swelling increases inositol 1,4,5-trisphosphate, calcium and cyclic AMP concentration but antagonizes phosphorylase activation by Ca2(+)-dependent hormones.

Authors:  A Baquet; A J Meijer; L Hue
Journal:  FEBS Lett       Date:  1991-01-14       Impact factor: 4.124

7.  Control of gluconeogenesis and of enzymes of glycogen metabolism in isolated rat hepatocytes. A parallel study of the effect of phenylephrine and of glucagon.

Authors:  L Hue; J E Felíu; H G Hers
Journal:  Biochem J       Date:  1978-12-15       Impact factor: 3.857

8.  Liver cell volume and protein synthesis.

Authors:  B Stoll; W Gerok; F Lang; D Häussinger
Journal:  Biochem J       Date:  1992-10-01       Impact factor: 3.857

9.  Mechanism of activation of liver glycogen synthase by swelling.

Authors:  A J Meijer; A Baquet; L Gustafson; G M van Woerkom; L Hue
Journal:  J Biol Chem       Date:  1992-03-25       Impact factor: 5.157

10.  Regulation of liver cell volume and proteolysis by glucagon and insulin.

Authors:  S Vom Dahl; C Hallbrucker; F Lang; W Gerok; D Häussinger
Journal:  Biochem J       Date:  1991-09-15       Impact factor: 3.857
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  7 in total

Review 1.  Specific features of glycogen metabolism in the liver.

Authors:  M Bollen; S Keppens; W Stalmans
Journal:  Biochem J       Date:  1998-11-15       Impact factor: 3.857

2.  Fructose-induced increase in intracellular free Mg2+ ion concentration in rat hepatocytes: relation with the enzymes of glycogen metabolism.

Authors:  V Gaussin; P Gailly; J M Gillis; L Hue
Journal:  Biochem J       Date:  1997-09-15       Impact factor: 3.857

3.  Glucagon activates Ca2+ and Cl- channels in rat hepatocytes.

Authors:  Edoardo C Aromataris; Michael L Roberts; Greg J Barritt; Grigori Y Rychkov
Journal:  J Physiol       Date:  2006-03-31       Impact factor: 5.182

4.  Modulation of phosphoenolpyruvate carboxykinase mRNA levels by the hepatocellular hydration state.

Authors:  W P Newsome; U Warskulat; B Noe; M Wettstein; B Stoll; W Gerok; D Häussinger
Journal:  Biochem J       Date:  1994-12-01       Impact factor: 3.857

5.  Evidence that stimulation of plasma-membrane Ca2+ inflow is an early action of glucagon and dibutyryl cyclic AMP in rat hepatocytes.

Authors:  F L Bygrave; A Gamberucci; R Fulceri; A Benedetti
Journal:  Biochem J       Date:  1993-05-15       Impact factor: 3.857

6.  Regulation of oxidative degradation of L-lysine in rat liver mitochondria.

Authors:  P W Scislowski; A R Foster; M F Fuller
Journal:  Biochem J       Date:  1994-06-15       Impact factor: 3.857

7.  Fed state prior to hemorrhagic shock and polytrauma in a porcine model results in altered liver transcriptomic response.

Authors:  Charles Determan; Rebecca Anderson; Aaron Becker; Nancy Witowski; Elizabeth Lusczek; Kristine Mulier; Greg J Beilman
Journal:  PLoS One       Date:  2014-06-17       Impact factor: 3.240
  7 in total

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