Literature DB >> 8010974

Regulation of oxidative degradation of L-lysine in rat liver mitochondria.

P W Scislowski1, A R Foster, M F Fuller.   

Abstract

The generation of 14CO2 from [1-14C]lysine by hepatic mitochondria through the saccharopine pathway is controlled by intramitochondrial concentrations of lysine, 2-oxoglutarate and NADPH. Mitochondria, isolated from rats pre-treated with glucagon, exhibited higher activities of L-lysine: 2-oxoglutarate reductase, saccharopine dehydrogenase and 2-aminoadipate aminotransferase. The flux through this pathway is stimulated in liver mitochondria after glucagon treatment. Multiple regulation of lysine oxidation in liver mitochondria confirms a complex mechanism of 'mitochondrial activation' by glucagon.

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Year:  1994        PMID： 8010974      PMCID： PMC1138248          DOI： 10.1042/bj3000887

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  32 in total

1.  Cell shrinkage follows, rather than mediates, the short-term effects of glucagon on carbohydrate metabolism.

Authors:  V Gaussin; A Baquet; L Hue
Journal:  Biochem J       Date:  1992-10-01       Impact factor: 3.857

2.  Developmental changes of L-lysine-ketoglutarate reductase in rat brain and liver.

Authors:  V V Rao; X Pan; Y F Chang
Journal:  Comp Biochem Physiol B       Date:  1992-09

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Authors:  D K MYERS; E C SLATER
Journal:  Biochem J       Date:  1957-12       Impact factor: 3.857

4.  Turnover of carbamyl-phosphate synthase, of other mitochondrial enzymes and of rat tissues. Effect of diet and of thyroidectomy.

Authors:  M Nicoletti; C Guerri; S Grisolia
Journal:  Eur J Biochem       Date:  1977-05-16

5.  Role of glucagon in disposal of an amino acid load.

Authors:  G Boden; L Tappy; F Jadali; R D Hoeldtke; I Rezvani; O E Owen
Journal:  Am J Physiol       Date:  1990-08

6.  Adaptive response of lysine and threonine degrading enzymes in adult rats.

Authors:  S H Chu; D M Hegsted
Journal:  J Nutr       Date:  1976-08       Impact factor: 4.798

7.  Inactivation of alpha-ketoglutarate dehydrogenase during oxidative decarboxylation of alpha-ketoadipic acid.

Authors:  V I Bunik; O G Pavlova
Journal:  FEBS Lett       Date:  1993-05-24       Impact factor: 4.124

8.  Mechanisms involved in hormone signal transduction across the mitochondrial membrane.

Authors:  A P Halestrap; P T Quinlan; A E Armston; D E Whipps
Journal:  Biochem Soc Trans       Date:  1985-08       Impact factor: 5.407

9.  Interaction between NAD-dependent isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase complex, and NADH:ubiquinone oxidoreductase.

Authors:  Z Porpaczy; B Sumegi; I Alkonyi
Journal:  J Biol Chem       Date:  1987-07-15       Impact factor: 5.157

10.  Urea synthesis in rats fed diet containing kidney beans.

Authors:  P W Scislowski; G Grant; I Harris; K Pickard; A Pusztai
Journal:  Biochem Int       Date:  1992-10
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  4 in total

1.  Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse.

Authors:  F Papes; E L Kemper; G Cord-Neto; F Langone; P Arruda
Journal:  Biochem J       Date:  1999-12-01       Impact factor: 3.857

2.  Purification and Characterization of the Bifunctional Enzyme Lysine-Ketoglutarate Reductase-Saccharopine Dehydrogenase from Maize.

Authors:  M. Goncalves-Butruille; P. Szajner; E. Torigoi; A. Leite; P. Arruda
Journal:  Plant Physiol       Date:  1996-03       Impact factor: 8.340

3.  Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn.

Authors:  Hai Pan; Kenneth Chen; Liping Chu; Francis Kinderman; Izydor Apostol; Gang Huang
Journal:  Protein Sci       Date:  2009-02       Impact factor: 6.725

4.  Advanced Glycation End Products, Oxidation Products, and the Extent of Atherosclerosis During the VA Diabetes Trial and Follow-up Study.

Authors:  Aramesh Saremi; Scott Howell; Dawn C Schwenke; Gideon Bahn; Paul J Beisswenger; Peter D Reaven
Journal:  Diabetes Care       Date:  2017-02-01       Impact factor: 19.112
  4 in total

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