Hepatocyte swelling increases inositol 1,4,5-trisphosphate, calcium and cyclic AMP concentration but antagonizes phosphorylase activation by Ca2(+)-dependent hormones.

Swelling of hepatocytes increases the concentration of inositol 1,4,5-trisphosphate, Ca2+ and cAMP, without activating glycogen phosphorylase. In these hepatocytes, the activation of phosphorylase by suboptimal concentrations of vasopressin or angiotensin II was partly antagonized.