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Literature DB >> 13295487

The preparation and function of the hypertensin-converting enzyme.

Abstract

It has been shown by use of isolated, perfused rat kidneys that hypertensin II is a potent vasoconstrictor substance while hypertensin I is not. Hence it would appear that in intact animals the pressor activity of hypertensin I results from its rapid conversion to hypertensin II. An enzyme which effects this conversion has been procured from horse plasma in a semipurified form by means of ammonium sulfate fractionation and isoelectric precipitation. A method is described for estimating the activity of the enzyme. An example of the use of the preparation in converting purified hypertensin I to hypertensin II has been described.

Entities: Chemical Disease Species

Keywords: ANGIOTONIN; ENZYMES

Mesh：

Substances：

Year: 1956 PMID： 13295487 PMCID： PMC2136590 DOI： 10.1084/jem.103.3.295

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

6 in total

1. A modified ninhydrin reagent for the photometric determination of amino acids and related compounds.

Authors: S MOORE; W H STEIN
Journal: J Biol Chem Date: 1954-12 Impact factor: 5.157

2. A method of assaying small amounts of hypertensin.

Authors: L T SKEGGS; J R KAHN; W H MARSH
Journal: Lab Invest Date: 1953 Mar-Apr Impact factor: 5.662

3. Artificial kidney; construction and operation of an improved continuous dialyzer.

Authors: L T SKEGGS; J R LEONARDS; C R HEISLER
Journal: Proc Soc Exp Biol Med Date: 1949-12

4. The purification of hypertensin I.

Authors: L T SKEGGS; W H MARSH; J R KAHN; N P SHUMWAY
Journal: J Exp Med Date: 1954-10-01 Impact factor: 14.307

5. The existence of two forms of hypertensin.

Authors: L T SKEGGS; W H MARSH; J R KAHN; N P SHUMWAY
Journal: J Exp Med Date: 1954-03 Impact factor: 14.307

6. Amino acid composition and electrophoretic properties of hypertensin I.

Authors: L T SKEGGS; W H MARSH; J R KAHN; N P SHUMWAY
Journal: J Exp Med Date: 1955-10-01 Impact factor: 14.307

6 in total

134 in total

10. Novel activity of angiotensin-converting enzyme. Hydrolysis of cholecystokinin and gastrin analogues with release of the amidated C-terminal dipeptide.

Authors: P Dubreuil; P Fulcrand; M Rodriguez; H Fulcrand; J Laur; J Martinez
Journal: Biochem J Date: 1989-08-15 Impact factor: 3.857

The preparation and function of the hypertensin-converting enzyme.

1. A modified ninhydrin reagent for the photometric determination of amino acids and related compounds.

2. A method of assaying small amounts of hypertensin.

3. Artificial kidney; construction and operation of an improved continuous dialyzer.

4. The purification of hypertensin I.

5. The existence of two forms of hypertensin.

6. Amino acid composition and electrophoretic properties of hypertensin I.

Review 1. Historical perspective of the renin-angiotensin system.

2. [Studies on serum angiotensinase. II. Clinical results in hypertension and liver diseases].

3. [Research on the production of angiotensin II (hypertensin II)].

4. [Angiotensin].

5. [Circulatory studies with synthetic hypertensin II].

6. [Not Available].

7. Pain-producing substance in human inflammatory exudates and plasma.

8. [Renin and hypertension, physiological or pathological agents?].

9. [Effect of synthetic hypertensin II on PAH- and inulin clearance, on renal hemodynamics and on diuresis in man].

10. Novel activity of angiotensin-converting enzyme. Hydrolysis of cholecystokinin and gastrin analogues with release of the amidated C-terminal dipeptide.