Literature DB >> 1323117

Stable association between the bovine papillomavirus E5 transforming protein and activated platelet-derived growth factor receptor in transformed mouse cells.

L Petti1, D DiMaio.   

Abstract

The 44-amino acid E5 transforming protein of bovine papillomavirus is the shortest protein known to induce tumorigenic transformation of fibroblasts. We showed previously that expression of the E5 protein activates the cellular beta receptor for platelet-derived growth factor (PDGF) and proposed that the activated receptor transmits the transforming signal to the cell. Here we use coimmunoprecipitation analysis to show that the E5 protein and the activated PDGF receptor exist in a stable complex in transformed mouse C127 cells. These results suggest a distinct mechanism of growth factor receptor activation and provide further evidence that the PDGF receptor is an important target of the E5 protein.

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Year:  1992        PMID： 1323117      PMCID： PMC49578          DOI： 10.1073/pnas.89.15.6736

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  34 in total

1.  A glutamine residue in the membrane-associating domain of the bovine papillomavirus type 1 E5 oncoprotein mediates its binding to a transmembrane component of the vacuolar H(+)-ATPase.

Authors:  D J Goldstein; R Kulke; D Dimaio; R Schlegel
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

2.  The central hydrophobic domain of the bovine papillomavirus E5 transforming protein can be functionally replaced by many hydrophobic amino acid sequences containing a glutamine.

Authors:  R Kulke; B H Horwitz; T Zibello; D DiMaio
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

3.  Transforming activity of a 16-amino-acid segment of the bovine papillomavirus E5 protein linked to random sequences of hydrophobic amino acids.

Authors:  B H Horwitz; D L Weinstat; D DiMaio
Journal:  J Virol       Date:  1989-11       Impact factor: 5.103

4.  44-amino-acid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl-terminal amino acids.

Authors:  B H Horwitz; A L Burkhardt; R Schlegel; D DiMaio
Journal:  Mol Cell Biol       Date:  1988-10       Impact factor: 4.272

5.  The E5 transforming gene of bovine papillomavirus encodes a small, hydrophobic polypeptide.

Authors:  R Schlegel; M Wade-Glass; M S Rabson; Y C Yang
Journal:  Science       Date:  1986-07-25       Impact factor: 47.728

6.  Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16.

Authors:  C Leptak; S Ramon y Cajal; R Kulke; B H Horwitz; D J Riese; G P Dotto; D DiMaio
Journal:  J Virol       Date:  1991-12       Impact factor: 5.103

7.  Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation.

Authors:  J B Bolen; C J Thiele; M A Israel; W Yonemoto; L A Lipsich; J S Brugge
Journal:  Cell       Date:  1984-10       Impact factor: 41.582

8.  Polyoma virus transforming protein associates with the product of the c-src cellular gene.

Authors:  S A Courtneidge; A E Smith
Journal:  Nature       Date:  1983 Jun 2-8       Impact factor: 49.962

9.  Genetic and biochemical definition of the bovine papillomavirus E5 transforming protein.

Authors:  A Burkhardt; D DiMaio; R Schlegel
Journal:  EMBO J       Date:  1987-08       Impact factor: 11.598

10.  The E5 oncoprotein of bovine papillomavirus binds to a 16 kd cellular protein.

Authors:  D J Goldstein; R Schlegel
Journal:  EMBO J       Date:  1990-01       Impact factor: 11.598
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  54 in total

1.  Upregulation of tyrosine kinase TKT by the Epstein-Barr virus transactivator Zta.

Authors:  J Lu; S Y Chen; H H Chua; Y S Liu; Y T Huang; Y Chang; J Y Chen; T S Sheen; C H Tsai
Journal:  J Virol       Date:  2000-08       Impact factor: 5.103

2.  Construction and maintenance of randomized retroviral expression libraries for transmembrane protein engineering.

Authors:  Sara A Marlatt; Yong Kong; Tobin J Cammett; Gregory Korbel; James P Noonan; Daniel Dimaio
Journal:  Protein Eng Des Sel       Date:  2010-12-10       Impact factor: 1.650

3.  Biologically active LIL proteins built with minimal chemical diversity.

Authors:  Erin N Heim; Jez L Marston; Ross S Federman; Anne P B Edwards; Alexander G Karabadzhak; Lisa M Petti; Donald M Engelman; Daniel DiMaio
Journal:  Proc Natl Acad Sci U S A       Date:  2015-08-10       Impact factor: 11.205

4.  Productive interaction between transmembrane mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor beta receptor.

Authors:  Char-Chang Lai; Anne P B Edwards; Daniel DiMaio
Journal:  J Virol       Date:  2005-02       Impact factor: 5.103

5.  Packing contacts can mediate highly specific interactions between artificial transmembrane proteins and the PDGFbeta receptor.

Authors:  Jennifer B Ptacek; Anne P B Edwards; Lisa L Freeman-Cook; Daniel DiMaio
Journal:  Proc Natl Acad Sci U S A       Date:  2007-07-03       Impact factor: 11.205

6.  A single amino acid substitution converts a transmembrane protein activator of the platelet-derived growth factor β receptor into an inhibitor.

Authors:  Lisa M Petti; Kristina Talbert-Slagle; Megan L Hochstrasser; Daniel DiMaio
Journal:  J Biol Chem       Date:  2013-08-01       Impact factor: 5.157

7.  Replacement of interleukin-2 (IL-2)-generated mitogenic signals by a mink cell focus-forming (MCF) or xenotropic virus-induced IL-9-dependent autocrine loop: implications for MCF virus-induced leukemogenesis.

Authors:  M M Flubacher; S E Bear; P N Tsichlis
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

8.  The genomes of the animal papillomaviruses European elk papillomavirus, deer papillomavirus, and reindeer papillomavirus contain a novel transforming gene (E9) near the early polyadenylation site.

Authors:  A Eriksson; A C Stewart; J Moreno-Lopéz; U Pettersson
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

Review 9.  The bovine papillomavirus E5 protein and the PDGF beta receptor: it takes two to tango.

Authors:  Kristina Talbert-Slagle; Daniel DiMaio
Journal:  Virology       Date:  2008-11-06       Impact factor: 3.616

10.  The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface.

Authors:  J C Mulloy; R W Crownley; J Fullen; W J Leonard; G Franchini
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103
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