Literature DB >> 15650217

Productive interaction between transmembrane mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor beta receptor.

Char-Chang Lai1, Anne P B Edwards, Daniel DiMaio.   

Abstract

The bovine papillomavirus E5 protein is a 44-amino-acid transmembrane protein that transforms cells by binding to the transmembrane region of the cellular platelet-derived growth factor (PDGF) beta receptor, resulting in sustained receptor signaling. However, there are published reports that certain mutants with amino acid substitutions in the membrane-spanning segment of the E5 protein transform cells without activating the PDGF beta receptor. We re-examined several of these transmembrane mutants, and here we present five lines of evidence that these mutants do in fact activate the PDGF beta receptor, resulting in cellular signaling and transformation.

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Year:  2005        PMID： 15650217      PMCID： PMC544141          DOI： 10.1128/JVI.79.3.1924-1929.2005

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  23 in total

1.  c-Src activation by the E5 oncoprotein enables transformation independently of PDGF receptor activation.

Authors:  Frank A Suprynowicz; Astrid Baege; Iruvanti Sunitha; Richard Schlegel
Journal:  Oncogene       Date:  2002-03-07       Impact factor: 9.867

2.  Stable association between the bovine papillomavirus E5 transforming protein and activated platelet-derived growth factor receptor in transformed mouse cells.

Authors:  L Petti; D DiMaio
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205

3.  Selection and characterization of small random transmembrane proteins that bind and activate the platelet-derived growth factor beta receptor.

Authors:  Lisa L Freeman-Cook; Ann M Dixon; Jennifer B Frank; Yu Xia; Lara Ely; Mark Gerstein; Donald M Engelman; Daniel DiMaio
Journal:  J Mol Biol       Date:  2004-05-14       Impact factor: 5.469

4.  An intact PDGF signaling pathway is required for efficient growth transformation of mouse C127 cells by the bovine papillomavirus E5 protein.

Authors:  D J Riese; D DiMaio
Journal:  Oncogene       Date:  1995-04-06       Impact factor: 9.867

5.  Specific interaction between the bovine papillomavirus E5 transforming protein and the beta receptor for platelet-derived growth factor in stably transformed and acutely transfected cells.

Authors:  L Petti; D DiMaio
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103

6.  Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation.

Authors:  M Kovalenko; A Gazit; A Böhmer; C Rorsman; L Rönnstrand; C H Heldin; J Waltenberger; F D Böhmer; A Levitzki
Journal:  Cancer Res       Date:  1994-12-01       Impact factor: 12.701

7.  The transmembrane domain of the E5 oncoprotein contains functionally discrete helical faces.

Authors:  A J Adduci; R Schlegel
Journal:  J Biol Chem       Date:  1999-04-09       Impact factor: 5.157

8.  The bovine papillomavirus type 1 E5 transforming protein specifically binds and activates the beta-type receptor for the platelet-derived growth factor but not other related tyrosine kinase-containing receptors to induce cellular transformation.

Authors:  D J Goldstein; W Li; L M Wang; M A Heidaran; S Aaronson; R Shinn; R Schlegel; J H Pierce
Journal:  J Virol       Date:  1994-07       Impact factor: 5.103

9.  Activation of the platelet-derived growth factor receptor by the bovine papillomavirus E5 transforming protein.

Authors:  L Petti; L A Nilson; D DiMaio
Journal:  EMBO J       Date:  1991-04       Impact factor: 11.598

10.  The BPV-1 E5 protein, the 16 kDa membrane pore-forming protein and the PDGF receptor exist in a complex that is dependent on hydrophobic transmembrane interactions.

Authors:  D J Goldstein; T Andresson; J J Sparkowski; R Schlegel
Journal:  EMBO J       Date:  1992-12       Impact factor: 11.598
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  7 in total

1.  Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation.

Authors:  Heather A Galick; Scott Kathe; Minmin Liu; Susan Robey-Bond; Dawit Kidane; Susan S Wallace; Joann B Sweasy
Journal:  Proc Natl Acad Sci U S A       Date:  2013-08-12       Impact factor: 11.205

2.  Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation.

Authors:  Joann B Sweasy; Tieming Lang; Daniela Starcevic; Ka-Wai Sun; Char-Chang Lai; Daniel Dimaio; Shibani Dalal
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-22       Impact factor: 11.205

Review 3.  The bovine papillomavirus E5 protein and the PDGF beta receptor: it takes two to tango.

Authors:  Kristina Talbert-Slagle; Daniel DiMaio
Journal:  Virology       Date:  2008-11-06       Impact factor: 3.616

Review 4.  The E5 proteins.

Authors:  Daniel DiMaio; Lisa M Petti
Journal:  Virology       Date:  2013-05-31       Impact factor: 3.616

5.  The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation.

Authors:  Tieming Lang; Shibani Dalal; Anna Chikova; Daniel DiMaio; Joann B Sweasy
Journal:  Mol Cell Biol       Date:  2007-05-25       Impact factor: 4.272

6.  Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.

Authors:  Antonia A Nemec; Katherine A Donigan; Drew L Murphy; Joachim Jaeger; Joann B Sweasy
Journal:  J Biol Chem       Date:  2012-05-09       Impact factor: 5.157

Review 7.  Papillomavirus E5: the smallest oncoprotein with many functions.

Authors:  Aldo Venuti; Francesca Paolini; Lubna Nasir; Annunziata Corteggio; Sante Roperto; Maria S Campo; Giuseppe Borzacchiello
Journal:  Mol Cancer       Date:  2011-11-11       Impact factor: 27.401
  7 in total

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