Literature DB >> 3014660

The E5 transforming gene of bovine papillomavirus encodes a small, hydrophobic polypeptide.

R Schlegel, M Wade-Glass, M S Rabson, Y C Yang.   

Abstract

Bovine papillomavirus (BPV-1) contains two independent transforming genes that have been mapped to the E5 and E6 open reading frames (ORF's). The E5 transforming protein was identified by means of an antiserum against a synthetic peptide corresponding to the 20 COOH-terminal amino acids of the E5 ORF. The E5 polypeptide is the smallest viral transforming protein yet characterized; it had an apparent size of 7 kilodaltons. The transforming polypeptide is encoded entirely within the second half of the E5 ORF and its predicted amino acid composition is very unusual; 68% of the amino acids are strongly hydrophobic and 34% are leucine. Cell fractionation studies localized this polypeptide predominantly to cellular membranes.

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Year:  1986        PMID： 3014660     DOI： 10.1126/science.3014660

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  87 in total

1.  A glutamine residue in the membrane-associating domain of the bovine papillomavirus type 1 E5 oncoprotein mediates its binding to a transmembrane component of the vacuolar H(+)-ATPase.

Authors:  D J Goldstein; R Kulke; D Dimaio; R Schlegel
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

2.  Stable association between the bovine papillomavirus E5 transforming protein and activated platelet-derived growth factor receptor in transformed mouse cells.

Authors:  L Petti; D DiMaio
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205

3.  Construction and maintenance of randomized retroviral expression libraries for transmembrane protein engineering.

Authors:  Sara A Marlatt; Yong Kong; Tobin J Cammett; Gregory Korbel; James P Noonan; Daniel Dimaio
Journal:  Protein Eng Des Sel       Date:  2010-12-10       Impact factor: 1.650

4.  Biologically active LIL proteins built with minimal chemical diversity.

Authors:  Erin N Heim; Jez L Marston; Ross S Federman; Anne P B Edwards; Alexander G Karabadzhak; Lisa M Petti; Donald M Engelman; Daniel DiMaio
Journal:  Proc Natl Acad Sci U S A       Date:  2015-08-10       Impact factor: 11.205

5.  Reindeer papillomavirus transforming properties correlate with a highly conserved E5 region.

Authors:  J Moreno-Lopez; H Ahola; A Eriksson; P Bergman; U Pettersson
Journal:  J Virol       Date:  1987-11       Impact factor: 5.103

6.  Mutational analysis of the 3' open reading frames and the splice junction at nucleotide 3225 of bovine papillomavirus type 1.

Authors:  P L Hermonat; P M Howley
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103

7.  Biologic properties and nucleotide sequence analysis of human papillomavirus type 51.

Authors:  O Lungu; C P Crum; S Silverstein
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

8.  Mutational analysis of bovine papillomavirus type 1 E5 peptide domains involved in induction of cellular DNA synthesis.

Authors:  J A Rawls; P M Loewenstein; M Green
Journal:  J Virol       Date:  1989-11       Impact factor: 5.103

9.  The genomes of the animal papillomaviruses European elk papillomavirus, deer papillomavirus, and reindeer papillomavirus contain a novel transforming gene (E9) near the early polyadenylation site.

Authors:  A Eriksson; A C Stewart; J Moreno-Lopéz; U Pettersson
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

Review 10.  The bovine papillomavirus E5 protein and the PDGF beta receptor: it takes two to tango.

Authors:  Kristina Talbert-Slagle; Daniel DiMaio
Journal:  Virology       Date:  2008-11-06       Impact factor: 3.616
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