| Literature DB >> 1318388 |
M S Springer1, E H Davidson, R J Britten.
Abstract
Measurements are reported of the thermal stability of DNA heteroduplexes between clones of the eta-globin pseudogene from a variety of primates. The known sequences of this 7.1-kb region differ from each over a range from 1.6% for human versus chimp to nearly 12% for human versus spider monkey. Thermal stability was determined by standard hydroxyapatite thermal elution, and the results show a precisely linear decrease in thermal stability with divergence. The slope of the regression line is 1.18% sequence divergence per degree centigrade reduction in thermal stability.Entities:
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Year: 1992 PMID: 1318388 DOI: 10.1007/bf00162994
Source DB: PubMed Journal: J Mol Evol ISSN: 0022-2844 Impact factor: 2.395