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Literature DB >> 1316194

Localization of genes and anonymous DNA probes on the short arm of chromosome 7.

Abstract

We have previously described the cytogenetic analysis of two patients with Greig cephalopolysyndactyly syndrome (GCPS) and various microdeletions on the short arm of Chromosome (Chr) 7. Using genes and anonymous DNA probes from 7p we analyzed the DNA of our patients for loss of heterozygosity, or we determined the copy number by semi-quantitative Southern hybridization. We have been able to show hemizygosity for the genes of INHBA, IGFBP1 and GLI3 in both patients and therefore can give the chromosomal assignment 7p12.3-p13. CRI-R944 and CRI-P137 map to the same region, whereas CRI-S207 can be assigned to 7p13-p14.2; TM102L, TS93, TS194, TM77 and TN177 showed no change and these probes map distal to 7p14.2.

Entities: Disease Gene Species

Mesh：

Substances：
DNA Probes
DNA

Year: 1992 PMID： 1316194 DOI： 10.1007/bf00355840

Source DB: PubMed Journal: Mamm Genome ISSN： 0938-8990 Impact factor: 2.957

15 in total

1. A TaqI RFLP detected by the probe TN157 (D7S145) at the human chromosome region 7p13-14.2.

Authors: K Wagner; P M Kroisel; W Rosenkranz
Journal: Nucleic Acids Res Date: 1991-03-11 Impact factor: 16.971

2. Twenty-five loci form a continuous linkage map of markers for human chromosome 7.

Authors: G M Lathrop; P O'Connell; M Leppert; Y Nakamura; M Farrall; L C Tsui; J M Lalouel; R White
Journal: Genomics Date: 1989-11 Impact factor: 5.736

3. Genetic linkage map of human chromosome 7 with 63 DNA markers.

Authors: D Barker; P Green; R Knowlton; J Schumm; E Lander; A Oliphant; H Willard; G Akots; V Brown; T Gravius
Journal: Proc Natl Acad Sci U S A Date: 1987-11 Impact factor: 11.205

4. Genomic sequencing.

Authors: G M Church; W Gilbert
Journal: Proc Natl Acad Sci U S A Date: 1984-04 Impact factor: 11.205

5. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors: A P Feinberg; B Vogelstein
Journal: Anal Biochem Date: 1983-07-01 Impact factor: 3.365

6. A familial reciprocal translocation t(3;7) (p21.1;p13) associated with the Greig polysyndactyly-craniofacial anomalies syndrome.

Authors: N Tommerup; F Nielsen
Journal: Am J Med Genet Date: 1983-11

7. Regional and physical mapping studies characterizing the Greig polysyndactyly 3;7 chromosome translocation, t(3;7)(p21.1;p13).

Authors: H Drabkin; M Sage; C Helms; P Green; R Gemmill; D Smith; P Erickson; I Hart; A Ferguson-Smith; F Ruddle
Journal: Genomics Date: 1989-05 Impact factor: 5.736

Localization of genes and anonymous DNA probes on the short arm of chromosome 7.

1. A TaqI RFLP detected by the probe TN157 (D7S145) at the human chromosome region 7p13-14.2.

2. Twenty-five loci form a continuous linkage map of markers for human chromosome 7.

3. Genetic linkage map of human chromosome 7 with 63 DNA markers.

4. Genomic sequencing.

5. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

6. A familial reciprocal translocation t(3;7) (p21.1;p13) associated with the Greig polysyndactyly-craniofacial anomalies syndrome.

7. Regional and physical mapping studies characterizing the Greig polysyndactyly 3;7 chromosome translocation, t(3;7)(p21.1;p13).

8. GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families.

9. Human gamma-chain genes are rearranged in leukaemic T cells and map to the short arm of chromosome 7.

10. Molecular genetic approach to the characterization of the "Down syndrome region" of chromosome 21.

1. Genes Downregulated in Endometriosis Are Located Near the Known Imprinting Genes.

2. The mouse mutant Polydactyly Nagoya (Pdn) defines a novel allele of the zinc finger gene Gli3.