| Literature DB >> 1313411 |
N G Fomukong1, J W Dale, T W Osborn, J M Grange.
Abstract
Gene probes derived from the insertion sequence IS986, which have previously been shown to differentiate isolates of Mycobacterium tuberculosis for epidemiological analysis, are also capable of distinguishing two groups of BCG vaccine strains. Most BCG strains have a single copy of IS986, at the same chromosomal site, while the Brazilian, Japanese and USSR strains have an additional copy at a different, common location. These results correlate with the results of previous antigenic analysis and may reflect a different clonal origin of the two groups of BCG strains.Entities:
Mesh:
Substances:
Year: 1992 PMID: 1313411 DOI: 10.1111/j.1365-2672.1992.tb01813.x
Source DB: PubMed Journal: J Appl Bacteriol ISSN: 0021-8847