Literature DB >> 1310775

Effect of zinc ions on the biochemical behavior of simian virus 40 small-t antigen expressed in bacteria.

R Goswami1, B Turk, K Enderle, A Howe, K Rundell.   

Abstract

The simian virus 40 small-t antigen contains 10 cysteine residues, 6 of which are organized in two CysXCysXXCys clusters. Mutation of individual Cys residues in the two clusters or mutation of specific residues found between these clusters causes pronounced instability of the protein in animal cells. Protein instability correlates with failure of the bacterially expressed mutant proteins to bind zinc ions, an interaction which allows purification of large amounts of small-t antigen in monomeric form.

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Year:  1992        PMID： 1310775      PMCID： PMC240925     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  17 in total

1.  Association of protein phosphatase 2A with polyoma virus medium tumor antigen.

Authors:  G Walter; R Ruediger; C Slaughter; M Mumby
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

2.  Purification and functional properties of simian virus 40 large and small T antigens overproduced in insect cells.

Authors:  C I Murphy; B Weiner; I Bikel; H Piwnica-Worms; M K Bradley; D M Livingston
Journal:  J Virol       Date:  1988-08       Impact factor: 5.103

3.  Purification of biologically active simian virus 40 small tumor antigen.

Authors:  I Bikel; T M Roberts; M T Bladon; R Green; E Amann; D M Livingston
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

4.  Association of simian virus 40 small-t antigen with the 61-kilodalton component of a cellular protein complex.

Authors:  B Joshi; K Rundell
Journal:  J Virol       Date:  1990-11       Impact factor: 5.103

5.  Papillomavirus polypeptides E6 and E7 are zinc-binding proteins.

Authors:  M S Barbosa; D R Lowy; J T Schiller
Journal:  J Virol       Date:  1989-03       Impact factor: 5.103

6.  Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.

Authors:  D C Pallas; L K Shahrik; B L Martin; S Jaspers; T B Miller; D L Brautigan; T M Roberts
Journal:  Cell       Date:  1990-01-12       Impact factor: 41.582

7.  Mutational analysis of simian virus 40 small-t antigen.

Authors:  P Jog; B Joshi; V Dhamankar; M J Imperiale; J Rutila; K Rundell
Journal:  J Virol       Date:  1990-06       Impact factor: 5.103

8.  Control of protein phosphatase 2A by simian virus 40 small-t antigen.

Authors:  S I Yang; R L Lickteig; R Estes; K Rundell; G Walter; M C Mumby
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272

9.  Characterization of a zinc blotting technique: evidence that a retroviral gag protein binds zinc.

Authors:  L A Schiff; M L Nibert; B N Fields
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205

Review 10.  The steroid and thyroid hormone receptor superfamily.

Authors:  R M Evans
Journal:  Science       Date:  1988-05-13       Impact factor: 47.728
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  10 in total

Review 1.  Role of Zn2+ ions in host-virus interactions.

Authors:  Maciej Lazarczyk; Michel Favre
Journal:  J Virol       Date:  2008-09-10       Impact factor: 5.103

2.  A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays.

Authors:  A Porrás; J Bennett; A Howe; K Tokos; N Bouck; B Henglein; S Sathyamangalam; B Thimmapaya; K Rundell
Journal:  J Virol       Date:  1996-10       Impact factor: 5.103

3.  Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation.

Authors:  S Mungre; K Enderle; B Turk; A Porrás; Y Q Wu; M C Mumby; K Rundell
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

4.  Mutation of a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and phosphatidylinositol-3 kinase, activation of c-fos expression, and cellular transformation.

Authors:  G M Glenn; W Eckhart
Journal:  J Virol       Date:  1993-04       Impact factor: 5.103

Review 5.  Small tumor antigen of polyomaviruses: role in viral life cycle and cell transformation.

Authors:  Kamel Khalili; Ilker Kudret Sariyer; Mahmut Safak
Journal:  J Cell Physiol       Date:  2008-05       Impact factor: 6.384

6.  Simian virus 40 small-t antigen stimulates viral DNA replication in permissive monkey cells.

Authors:  C Cicala; M L Avantaggiati; A Graessmann; K Rundell; A S Levine; M Carbone
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103

7.  Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus.

Authors:  R Ruediger; D Roeckel; J Fait; A Bergqvist; G Magnusson; G Walter
Journal:  Mol Cell Biol       Date:  1992-11       Impact factor: 4.272

8.  Simian virus 40 small-t antigen binds two zinc ions.

Authors:  B Turk; A Porras; M C Mumby; K Rundell
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103

9.  The Oncogenic Small Tumor Antigen of Merkel Cell Polyomavirus Is an Iron-Sulfur Cluster Protein That Enhances Viral DNA Replication.

Authors:  Sabrina H Tsang; Ranran Wang; Eiko Nakamaru-Ogiso; Simon A B Knight; Christopher B Buck; Jianxin You
Journal:  J Virol       Date:  2015-11-25       Impact factor: 5.103

10.  Structural basis of PP2A inhibition by small t antigen.

Authors:  Uhn Soo Cho; Seamus Morrone; Anna A Sablina; Jason D Arroyo; William C Hahn; Wenqing Xu
Journal:  PLoS Biol       Date:  2007-08       Impact factor: 8.029
  10 in total

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