Literature DB >> 8388518

Simian virus 40 small-t antigen binds two zinc ions.

B Turk1, A Porras, M C Mumby, K Rundell.   

Abstract

Six cysteine residues of the simian virus 40 small-t antigen (small-t) are important for stability of the protein. Stability has been shown to be related to the ability of small-t to bind zinc ions in vitro. Purified small-t expressed either in bacteria or from baculovirus vectors binds two molecules of zinc per molecule of protein. Thus, small-t may resemble GAL4, which contains a Zn(II)2Cys6 binuclear cluster.

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Year:  1993        PMID： 8388518      PMCID： PMC237723     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  21 in total

1.  New region of the simian virus 40 genome required for efficient viral transformation.

Authors:  N Bouck; N Beales; T Shenk; P Berg; G di Mayorca
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

2.  Interaction of simian virus 40 small-T antigen produced in bacteria with 56K and 32K proteins of animal cells.

Authors:  A Bossert; P Mulgaonkar; K Rundell
Journal:  J Virol       Date:  1985-10       Impact factor: 5.103

3.  Purification and functional properties of simian virus 40 large and small T antigens overproduced in insect cells.

Authors:  C I Murphy; B Weiner; I Bikel; H Piwnica-Worms; M K Bradley; D M Livingston
Journal:  J Virol       Date:  1988-08       Impact factor: 5.103

4.  Monoclonal antibodies specific for simian virus 40 tumor antigens.

Authors:  E Harlow; L V Crawford; D C Pim; N M Williamson
Journal:  J Virol       Date:  1981-09       Impact factor: 5.103

5.  Properties of simian virus 40 small t antigen overproduced in bacteria.

Authors:  C S Thummel; T L Burgess; R Tjian
Journal:  J Virol       Date:  1981-02       Impact factor: 5.103

6.  Construction and analysis of viable deletion mutants of simian virus 40.

Authors:  T E Shenk; J Carbon; P Berg
Journal:  J Virol       Date:  1976-05       Impact factor: 5.103

7.  The zinc finger region of simian virus 40 large T antigen.

Authors:  G Loeber; R Parsons; P Tegtmeyer
Journal:  J Virol       Date:  1989-01       Impact factor: 5.103

8.  The roles of the simian virus 40 tumor antigens in transformation of Chinese hamster lung cells.

Authors:  R G Martin; V P Setlow; C A Edwards; D Vembu
Journal:  Cell       Date:  1979-07       Impact factor: 41.582

9.  Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus.

Authors:  R Ruediger; D Roeckel; J Fait; A Bergqvist; G Magnusson; G Walter
Journal:  Mol Cell Biol       Date:  1992-11       Impact factor: 4.272

10.  Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.

Authors:  D M Virshup; M G Kauffman; T J Kelly
Journal:  EMBO J       Date:  1989-12-01       Impact factor: 11.598
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  14 in total

Review 1.  Role of Zn2+ ions in host-virus interactions.

Authors:  Maciej Lazarczyk; Michel Favre
Journal:  J Virol       Date:  2008-09-10       Impact factor: 5.103

2.  Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens.

Authors:  R Ruediger; K Fields; G Walter
Journal:  J Virol       Date:  1999-01       Impact factor: 5.103

3.  A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays.

Authors:  A Porrás; J Bennett; A Howe; K Tokos; N Bouck; B Henglein; S Sathyamangalam; B Thimmapaya; K Rundell
Journal:  J Virol       Date:  1996-10       Impact factor: 5.103

4.  Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation.

Authors:  S Mungre; K Enderle; B Turk; A Porrás; Y Q Wu; M C Mumby; K Rundell
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

5.  Mutations in a CCHC zinc-binding motif of the reovirus sigma 3 protein decrease its intracellular stability.

Authors:  T Mabrouk; G Lemay
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

6.  The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain.

Authors:  A Srinivasan; A J McClellan; J Vartikar; I Marks; P Cantalupo; Y Li; P Whyte; K Rundell; J L Brodsky; J M Pipas
Journal:  Mol Cell Biol       Date:  1997-08       Impact factor: 4.272

7.  Zinc-binding and protein-protein interactions mediated by the polyomavirus large T antigen zinc finger.

Authors:  P E Rose; B S Schaffhausen
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103

Review 8.  Small tumor antigen of polyomaviruses: role in viral life cycle and cell transformation.

Authors:  Kamel Khalili; Ilker Kudret Sariyer; Mahmut Safak
Journal:  J Cell Physiol       Date:  2008-05       Impact factor: 6.384

9.  Simian virus 40 small-t antigen stimulates viral DNA replication in permissive monkey cells.

Authors:  C Cicala; M L Avantaggiati; A Graessmann; K Rundell; A S Levine; M Carbone
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103

10.  SV40 reporter viruses.

Authors:  Rebecca B Katzman; Mark Seeger; Kathleen Rundell
Journal:  J Virol Methods       Date:  2008-04-09       Impact factor: 2.014
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