Literature DB >> 1309592

Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals.

M T Diaz-Meco1, I Dominguez, L Sanz, M M Municio, E Berra, M E Cornet, A Garcia de Herreros, T Johansen, J Moscat.   

Abstract

Cell growth and tumor transformation can be restrained in certain cell systems by the action of transforming growth factor beta (TGF-beta). It has been established that the mechanism whereby TGF-beta 1 inhibits cell growth does not interfere with the triggering of early mitogenic signal transduction mechanisms. Phospholipase C-catalyzed hydrolysis of phosphatidylcholine (PC) is a relatively late step in the cascade activated by growth factors. Therefore, conceivably activation of phospholipase C-catalyzed hydrolysis of PC could be the target of TGF-beta 1 action. In the study reported here, we demonstrate that TGF-beta 1 inhibits the coupling of ras p21 to the activation of PC hydrolysis, which appears to be critical for the antiproliferative effects of TGF-beta 1.

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Year:  1992        PMID： 1309592      PMCID： PMC364110          DOI： 10.1128/mcb.12.1.302-308.1992

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  29 in total

1.  A rapid method of total lipid extraction and purification.

Authors:  E G BLIGH; W J DYER
Journal:  Can J Biochem Physiol       Date:  1959-08

2.  Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21.

Authors:  A García de Herreros; I Dominguez; M T Diaz-Meco; G Graziani; M E Cornett; P H Guddal; T Johansen; J Moscat
Journal:  J Biol Chem       Date:  1991-04-15       Impact factor: 5.157

3.  Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II.

Authors:  M Laiho; F M Weis; F T Boyd; R A Ignotz; J Massagué
Journal:  J Biol Chem       Date:  1991-05-15       Impact factor: 5.157

Review 4.  Growth factors in development, transformation, and tumorigenesis.

Authors:  M Cross; T M Dexter
Journal:  Cell       Date:  1991-01-25       Impact factor: 41.582

Review 5.  Cooperation between oncogenes.

Authors:  T Hunter
Journal:  Cell       Date:  1991-01-25       Impact factor: 41.582

Review 6.  Signaling through phosphatidylcholine breakdown.

Authors:  J H Exton
Journal:  J Biol Chem       Date:  1990-01-05       Impact factor: 5.157

7.  Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation.

Authors:  M Laiho; J A DeCaprio; J W Ludlow; D M Livingston; J Massagué
Journal:  Cell       Date:  1990-07-13       Impact factor: 41.582

8.  TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.

Authors:  J A Pietenpol; R W Stein; E Moran; P Yaciuk; R Schlegel; R M Lyons; M R Pittelkow; K Münger; P M Howley; H L Moses
Journal:  Cell       Date:  1990-06-01       Impact factor: 41.582

9.  Phospholipase C-mediated hydrolysis of phosphatidylcholine is an important step in PDGF-stimulated DNA synthesis.

Authors:  P Larrodera; M E Cornet; M T Diaz-Meco; M Lopez-Barahona; I Diaz-Laviada; P H Guddal; T Johansen; J Moscat
Journal:  Cell       Date:  1990-06-15       Impact factor: 41.582

10.  The antiproliferative effect of type beta transforming growth factor occurs at a level distal from receptors for growth-activating factors.

Authors:  B Like; J Massagué
Journal:  J Biol Chem       Date:  1986-10-15       Impact factor: 5.157
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  12 in total

1.  Regulation of phosphatidylethanolamine degradation by enzyme(s) of subcellular fractions from cerebral cortex.

Authors:  J Strosznajder
Journal:  Neurochem Res       Date:  1997-10       Impact factor: 3.996

2.  Reversal of lipopolysaccharide-analog-induced antibody suppression by anti-transforming growth factor beta and indomethacin.

Authors:  M J Odean; A G Johnson; M Mohrman; A Hasegawa
Journal:  Infect Immun       Date:  1995-06       Impact factor: 3.441

3.  Protein kinase signalling pathways involved in the up-regulation of the rat alpha1(I) collagen gene by transforming growth factor beta1 and bone morphogenetic protein 2 in osteoblastic cells.

Authors:  S Palcy; D Goltzman
Journal:  Biochem J       Date:  1999-10-01       Impact factor: 3.857

4.  Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells.

Authors:  E Sancho; M R Vilá; L Sánchez-Pulido; J J Lozano; R Paciucci; M Nadal; M Fox; C Harvey; B Bercovich; N Loukili; A Ciechanover; S L Lin; F Sanz; X Estivill; A Valencia; T M Thomson
Journal:  Mol Cell Biol       Date:  1998-01       Impact factor: 4.272

5.  Subcellular distribution of protein kinase C (pKC) in erythrocytes and concentration of D-myo-inositol-1,4,5-trisphosphate (IP3) in platelets and monocytes of force-fed zinc-deficient rats.

Authors:  H P Roth; C Moser; M Kirchgessner
Journal:  Biol Trace Elem Res       Date:  1996       Impact factor: 3.738

6.  The co-mitogenic combination of transforming growth factor beta 1 and bombesin protects protein kinase C-delta from late-phase down-regulation, despite synergy in diacylglycerol accumulation.

Authors:  A R Olivier; G Hansra; T R Pettitt; M J Wakelam; P J Parker
Journal:  Biochem J       Date:  1996-09-01       Impact factor: 3.857

7.  Influence of alimentary zinc deficiency on the concentration of the second messengers D-myo-inositol-1,4,5-trisphosphate (IP3) and s,n-1,2-diacylglycerol (DAG) in testes and brain of force-fed rats.

Authors:  C Moser; H P Roth; M Kirchgessner
Journal:  Biol Trace Elem Res       Date:  1996-06       Impact factor: 3.738

8.  Phosphatidylcholine hydrolysis and c-myc expression are in collaborating mitogenic pathways activated by colony-stimulating factor 1.

Authors:  X X Xu; T G Tessner; C O Rock; S Jackowski
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272

9.  Protein kinase C-dependent stimulation of phospholipase D in phospholipase C-treated fibroblasts.

Authors:  Z Kiss; N Garamszegi
Journal:  Lipids       Date:  1993-06       Impact factor: 1.880

10.  NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus acquire a transformed phenotype.

Authors:  T Johansen; G Bjørkøy; A Overvatn; M T Diaz-Meco; T Traavik; J Moscat
Journal:  Mol Cell Biol       Date:  1994-01       Impact factor: 4.272
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