Literature DB >> 7768624

Reversal of lipopolysaccharide-analog-induced antibody suppression by anti-transforming growth factor beta and indomethacin.

M J Odean1, A G Johnson, M Mohrman, A Hasegawa.   

Abstract

Monophosphoryl lipid A and a synthetic, nontoxic monosaccharide analog of lipid A, termed GLA 60, both strongly suppressed antibody production when administered 1 to 2 days prior to antigen. Evidence is presented that this suppression was mediated by two cytokines, prostaglandin E and transforming growth factor beta, because it was reversed by multiple injections of the cyclooxygenase inhibitor indomethacin and by in vitro addition of antibody to transforming growth factor beta.

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Year:  1995        PMID： 7768624      PMCID： PMC173314          DOI： 10.1128/iai.63.6.2371-2373.1995

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  26 in total

Review 1.  Suppression of the immune response by microorganisms.

Authors:  J H Schwab
Journal:  Bacteriol Rev       Date:  1975-06

2.  Suppression of antigen and mitogen induced human T lymphocyte DNA synthesis by bacterial lipopolysaccharide: mediation by monocyte activation and production of prostaglandins.

Authors:  J J Ellner; P J Spagnuolo
Journal:  J Immunol       Date:  1979-12       Impact factor: 5.422

Review 3.  Bacterial endotoxins and host immune responses.

Authors:  D C Morrison; J L Ryan
Journal:  Adv Immunol       Date:  1979       Impact factor: 3.543

4.  Distribution of PGE and PGF2 alpha receptor proteins in the intracellular organelles of bovine corpora lutea.

Authors:  C V Rao; S B Mitra
Journal:  Methods Enzymol       Date:  1982       Impact factor: 1.600

5.  Inhibition of human B cell responsiveness by prostaglandin E2.

Authors:  N J Simkin; D F Jelinek; P E Lipsky
Journal:  J Immunol       Date:  1987-02-15       Impact factor: 5.422

6.  Prostaglandin E2 acts at two distinct pathways of T lymphocyte activation: inhibition of interleukin 2 production and down-regulation of transferrin receptor expression.

Authors:  S Chouaib; K Welte; R Mertelsmann; B Dupont
Journal:  J Immunol       Date:  1985-08       Impact factor: 5.422

7.  Regulation of human immunoglobulin production in vitro by prostaglandin E2.

Authors:  N D Staite; G S Panayi
Journal:  Clin Exp Immunol       Date:  1982-07       Impact factor: 4.330

8.  Human pulmonary macrophages utilize prostaglandins and transforming growth factor beta 1 to suppress lymphocyte activation.

Authors:  M D Roth; S H Golub
Journal:  J Leukoc Biol       Date:  1993-04       Impact factor: 4.962

9.  Tumor-mediated immunosuppression: prevention by inhibitors of prostaglandin synthesis.

Authors:  K D Grinwich; O J Plescia
Journal:  Prostaglandins       Date:  1977

10.  Immunization of dissociated spleen cell cultures from normal mice.

Authors:  R I Mishell; R W Dutton
Journal:  J Exp Med       Date:  1967-09-01       Impact factor: 14.307
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