Literature DB >> 2112426

Phospholipase C-mediated hydrolysis of phosphatidylcholine is an important step in PDGF-stimulated DNA synthesis.

P Larrodera1, M E Cornet, M T Diaz-Meco, M Lopez-Barahona, I Diaz-Laviada, P H Guddal, T Johansen, J Moscat.   

Abstract

Recent evidence suggests the involvement of phosphatidylcholine (PC) hydrolysis both in the control of normal cell growth and in transformation. We show here that the simple exogenous addition of Bacillus cereus PC-hydrolyzing phospholipase C (PC-PLC) is sufficient to elicit a potent mitogenic response in Swiss 3T3 fibroblasts by a mechanism that is independent of protein kinase C. Our results on the additivity and synergism between B. cereus PC-PLC, PDGF, and insulin in the mitogenic response indicate that this novel phospholipid degradative pathway may be important in the mitogenic signaling cascade activated by PDGF.

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Year:  1990        PMID： 2112426     DOI： 10.1016/0092-8674(90)90074-o

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  44 in total

1.  Phosphatidylcholine-specific phospholipase C and phospholipase D are respectively implicated in mitogen-activated protein kinase and nuclear factor kappaB activation in tumour-necrosis-factor-alpha-treated immature acute-myeloid-leukaemia cells.

Authors:  I Plo; D Lautier; T Levade; H Sekouri; J P Jaffrézou; G Laurent; A Bettaïeb
Journal:  Biochem J       Date:  2000-10-15       Impact factor: 3.857

2.  Adhesion is required for protein kinase C-dependent activation of the Na+/H+ antiporter by platelet-derived growth factor.

Authors:  M A Schwartz; C Lechene
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-01       Impact factor: 11.205

3.  Platelet-derived growth factor activates phospholipase D and chemotactic responses in vascular smooth muscle cells.

Authors:  C J Welsh; K Schmeichel; K McBride
Journal:  In Vitro Cell Dev Biol       Date:  1991-05

4.  Regulation of phosphatidylethanolamine degradation by enzyme(s) of subcellular fractions from cerebral cortex.

Authors:  J Strosznajder
Journal:  Neurochem Res       Date:  1997-10       Impact factor: 3.996

5.  Differential pathways (phospholipase C and phospholipase D) of bradykinin-induced biphasic 1,2-diacylglycerol formation in non-transformed and K-ras-transformed NIH-3T3 fibroblasts. Involvement of intracellular Ca2+ oscillations in phosphatidylcholine breakdown.

Authors:  T Fu; Y Okano; Y Nozawa
Journal:  Biochem J       Date:  1992-04-15       Impact factor: 3.857

6.  Differential induction of phosphatidylcholine hydrolysis, diacylglycerol formation and protein kinase C activation by epidermal growth factor and transforming growth factor-alpha in normal human skin fibroblasts and keratinocytes.

Authors:  N J Reynolds; H S Talwar; J J Baldassare; P A Henderson; J T Elder; J J Voorhees; G J Fisher
Journal:  Biochem J       Date:  1993-09-01       Impact factor: 3.857

7.  A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation.

Authors:  M T Diaz-Meco; E Berra; M M Municio; L Sanz; J Lozano; I Dominguez; V Diaz-Golpe; M T Lain de Lera; J Alcamí; C V Payá; F Arenzana-Seisedos; J L Virelizier; J Moscat
Journal:  Mol Cell Biol       Date:  1993-08       Impact factor: 4.272

8.  Phosphatidylcholine hydrolysis and c-myc expression are in collaborating mitogenic pathways activated by colony-stimulating factor 1.

Authors:  X X Xu; T G Tessner; C O Rock; S Jackowski
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272

9.  Vascular smooth-muscle cells contain AT1 angiotensin receptors coupled to phospholipase D activation.

Authors:  E J Freeman; E A Tallant
Journal:  Biochem J       Date:  1994-12-01       Impact factor: 3.857

10.  Multiple sources of sn-1,2-diacylglycerol in platelet-derived-growth-factor-stimulated Swiss 3T3 fibroblasts. Evidence for activation of phosphoinositidase C and phosphatidylcholine-specific phospholipase D.

Authors:  R Plevin; S J Cook; S Palmer; M J Wakelam
Journal:  Biochem J       Date:  1991-10-15       Impact factor: 3.857
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