Literature DB >> 130804

Treponemal antigen in immunopathogenesis of syphilitic glomerulonephritis.

D R Tourville, L H Byrd, D U Kim, D Zajd, I Lee, L B Reichman, S Baskin.   

Abstract

A patient with syphilitic glomerulonephritis had a renal biopsy and was treated for secondary syphilis. Light, electron, and immunofluorescence microscopic studies revealed an acute proliferative glomerulonephritis with subepithelial, intramembranous, and subendothelial immune complex deposits containing IgG, IgA, IgM, C4, and C3. Similar local deposits containing predominantly IgM were noted in areas of mesangial proliferation. Indirect fluorescent antibody studies employing rabbit treponemal antibody and sheep antirabbit globulin conjugate revealed the presence of treponemal antigen in the glomerular deposits. This finding provides strong evidence for the immunopathogenesis of the glomerular lesion as well as a causal link with Treponema pallidum.

Entities:  

Mesh：

Substances：

Year:  1976        PMID： 130804      PMCID： PMC2032412     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  19 in total

1.  Glomerular deposition of tumor antigen in membranous nephropathy associated with colonic carcinoma.

Authors:  W G Couser; J B Wagonfeld; B H Spargo; E J Lewis
Journal:  Am J Med       Date:  1974-12       Impact factor: 4.965

Review 2.  Immunologically mediated glomerular, tubular and interstitial renal disease.

Authors:  R T McCluskey; J Klassen
Journal:  N Engl J Med       Date:  1973-03-15       Impact factor: 91.245

3.  Glomerulonephritis with deposition of Australia antigen-antibody complexes in glomerular basement membrane.

Authors:  B Combes; J Shorey; A Barrera; P Stastny; E H Eigenbrodt; A R Hull; N W Carter
Journal:  Lancet       Date:  1971-07-31       Impact factor: 79.321

Review 4.  Glomerulonephritis (first of three parts).

Authors:  J P Merrill
Journal:  N Engl J Med       Date:  1974-01-31       Impact factor: 91.245

5.  Partial characterization of antigenic streptococcal plasma membrane components in acute glomerulonephritis.

Authors:  G Treser; M Semar; A Ty; I Agel; M A Franklin; K Lange
Journal:  J Clin Invest       Date:  1970-04       Impact factor: 14.808

6.  Evidence for soluble immune complexes in the pathogenesis of the glomerulonephritis of quartan malaria.

Authors:  P A Ward; J W Kibukamusoke
Journal:  Lancet       Date:  1969-02-08       Impact factor: 79.321

7.  Chronic membranous glomerulonephritis caused by hepatitis B antigen-antibody immune complexes.

Authors:  P F Kohler; R E Cronin; W S Hammond; D Olin; R I Carr
Journal:  Ann Intern Med       Date:  1974-10       Impact factor: 25.391

8.  Immunopathogenesis of syphilitic glomerulonephritis. Elution of antitreponemal antibody from glomerular immune-complex deposits.

Authors:  C N Gamble; J B Reardan
Journal:  N Engl J Med       Date:  1975-02-27       Impact factor: 91.245

9.  Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody.

Authors:  A H COONS; M H KAPLAN
Journal:  J Exp Med       Date:  1950-01-01       Impact factor: 14.307

10.  The human secretory immunoglobulin system: immunohistoligical localization of gamma A, secretory "piece," and lactoferrin in normal human tissues.

Authors:  D R Tourville; R H Adler; J Bienenstock; T B Tomasi
Journal:  J Exp Med       Date:  1969-02-01       Impact factor: 14.307
View more
  11 in total

1.  The Case | A 23-year-old Asian man with HIV infection and leg pitting edema.

Authors:  Yu-Chi Cheng; Wen-Wei Ku; Wing-Wai Wong; An-Hang Yang; Szu-Yuan Li
Journal:  Kidney Int       Date:  2015-09       Impact factor: 10.612

2.  Syphilis-Associated Acute Renal Failure and Hepatitis in the Setting of Human Immunodeficiency Virus Coinfection.

Authors:  Michael Sciaudone; Sarah E Rutstein; Claire E Farel
Journal:  Sex Transm Dis       Date:  2019-12       Impact factor: 2.830

Review 3.  Biological basis for syphilis.

Authors:  Rebecca E Lafond; Sheila A Lukehart
Journal:  Clin Microbiol Rev       Date:  2006-01       Impact factor: 26.132

4.  Circulating immune complexes in syphilitic nephropathy. A case report.

Authors:  J Sølling; K Sølling; K U Jacobsen; S Olsen; E From
Journal:  Br J Vener Dis       Date:  1978-02

5.  Persistent serum immune complexes in syphilis.

Authors:  S Engel; W Diezel
Journal:  Br J Vener Dis       Date:  1980-08

Review 6.  The immunopathobiology of syphilis: the manifestations and course of syphilis are determined by the level of delayed-type hypersensitivity.

Authors:  J Andrew Carlson; Ganary Dabiri; Bernard Cribier; Stewart Sell
Journal:  Am J Dermatopathol       Date:  2011-07       Impact factor: 1.533

7.  An unusual cause of membranous glomerulonephritis in a patient with HIV.

Authors:  Ying Maggie Chen; Luis A Marcos; Helen Liapis; Thomas H Steinberg; Aubrey R Morrison
Journal:  Int Urol Nephrol       Date:  2011-03-25       Impact factor: 2.370

8.  Circulating immune complexes in experimental syphilis: identification of treponemal antigens and specific antibodies to treponemal antigens in isolated complexes.

Authors:  R E Baughn; C B Adams; D M Musher
Journal:  Infect Immun       Date:  1983-11       Impact factor: 3.441

9.  Syphilis-related rapidly progressive glomerulonephritis: a case presentation.

Authors:  A Qi; P O Fiset; L Pilozzi-Edmonds
Journal:  BMC Nephrol       Date:  2021-05-25       Impact factor: 2.388

10.  The Structure of Treponema pallidum Tp0751 (Pallilysin) Reveals a Non-canonical Lipocalin Fold That Mediates Adhesion to Extracellular Matrix Components and Interactions with Host Cells.

Authors:  Michelle L Parker; Simon Houston; Helena Pětrošová; Karen V Lithgow; Rebecca Hof; Charmaine Wetherell; Wei-Chien Kao; Yi-Pin Lin; Tara J Moriarty; Rhodaba Ebady; Caroline E Cameron; Martin J Boulanger
Journal:  PLoS Pathog       Date:  2016-09-28       Impact factor: 6.823
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.