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Literature DB >> 638715

Circulating immune complexes in syphilitic nephropathy. A case report.

J Sølling, K Sølling, K U Jacobsen, S Olsen, E From.

Abstract

A case of transient nephrotic syndrome caused by secondary syphilis is described. A renal biopsy was performed revealing subepithelial hump-like electron-dense deposits and fusion of epithelial foot-processes. Complement C1q-binding-activity and anticomplementarity were demonstrated in the blood, indicating the presence of circulating immune complexes. This strongly suggests that circulating immune complexes are significant in the immunopathogenesis of syphilitic nephropathy.

Entities: Disease Gene

Mesh：

Substances：

Year: 1978 PMID： 638715 PMCID： PMC1045471 DOI： 10.1136/sti.54.1.53

Source DB: PubMed Journal: Br J Vener Dis ISSN： 0007-134X

14 in total

1. The glomerulopathy of congenital syphilis--an immune deposit disease.

Authors: B S Kaplan; F W Wiglesworth; M I Marks; K N Drummond
Journal: J Pediatr Date: 1972-12 Impact factor: 4.406

2. Circulating immune complexes in dermatitis herpetiformis.

Authors: J F Mowbray; A V Hoffbrand; E J Holborow; P P Seah; L Fry
Journal: Lancet Date: 1973-02-24 Impact factor: 79.321

3. The glomerulopathy of congenital syphilis. A curable immune-deposit disease.

Authors: A M Yuceoglu; I Sagel; G Tresser; E Wasserman; K Lange
Journal: JAMA Date: 1974-08-19 Impact factor: 56.272

4. Nephropathy of secondary syphilis. A clinical and pathological spectrum.

Authors: M S Bhorade; H B Carag; H J Lee; E V Potter; G Dunea
Journal: JAMA Date: 1971-05-17 Impact factor: 56.272

5. The nephrotic syndrome associated with secondary syphilis. An immune deposit disease.

Authors: G D Braunstein; E J Lewis; E G Galvanek; A Hamilton; W R Bell
Journal: Am J Med Date: 1970-05 Impact factor: 4.965

6. Immunochemical quantitation of antigens by single radial immunodiffusion.

Authors: G Mancini; A O Carbonara; J F Heremans
Journal: Immunochemistry Date: 1965-09

7. Detection of immune complexes.

Authors: V Agnello; A Gabriel; M Tai
Journal: J Invest Dermatol Date: 1976-09 Impact factor: 8.551

8. Circulating immune complexes in the serum in systemic lupus erythematosus and in carriers of hepatitis B antigen. Quantitation by binding to radiolabeled C1q.

Authors: U E Nydegger; P H Lambert; H Gerber; P A Miescher
Journal: J Clin Invest Date: 1974-08 Impact factor: 14.808

7. Suppression of lymphocyte response to concanavalin A by mucopolysaccharide material from Treponema pallidum-infected rabbits.

Authors: R F Bey; R C Johnson; T J Fitzgerald
Journal: Infect Immun Date: 1979-10 Impact factor: 3.441

8. Circulating immune complexes in experimental syphilis: identification of treponemal antigens and specific antibodies to treponemal antigens in isolated complexes.

Authors: R E Baughn; C B Adams; D M Musher
Journal: Infect Immun Date: 1983-11 Impact factor: 3.441

9. Accelerated lesion development in experimental syphilis.

Authors: T J Fitzgerald
Journal: Infect Immun Date: 1981-11 Impact factor: 3.441

9 in total

Circulating immune complexes in syphilitic nephropathy. A case report.

1. The glomerulopathy of congenital syphilis--an immune deposit disease.

2. Circulating immune complexes in dermatitis herpetiformis.

3. The glomerulopathy of congenital syphilis. A curable immune-deposit disease.

4. Nephropathy of secondary syphilis. A clinical and pathological spectrum.

5. The nephrotic syndrome associated with secondary syphilis. An immune deposit disease.

6. Immunochemical quantitation of antigens by single radial immunodiffusion.

7. Detection of immune complexes.

8. Circulating immune complexes in the serum in systemic lupus erythematosus and in carriers of hepatitis B antigen. Quantitation by binding to radiolabeled C1q.

9. Detection of circulating immune complexes in pathological human sera.

10. Treponemal antigen in immunopathogenesis of syphilitic glomerulonephritis.

1. Syphilis-Associated Acute Renal Failure and Hepatitis in the Setting of Human Immunodeficiency Virus Coinfection.

2. Simultaneous nephrotic syndrome and hepatitis in secondary syphilis: case report and review of the literature.

3. Early syphilitic hepatitis concomitant with nephrotic syndrome followed by acute kidney injury.

4. Persistent serum immune complexes in syphilis.

5. Secondary Syphilis Associated with Membranous Nephropathy and Acute Hepatitis in a Patient with HIV: A Case Report.

6. A 16-month-old boy with nephrotic syndrome of apparent idiopathic origin: Answer.

7. Suppression of lymphocyte response to concanavalin A by mucopolysaccharide material from Treponema pallidum-infected rabbits.

8. Circulating immune complexes in experimental syphilis: identification of treponemal antigens and specific antibodies to treponemal antigens in isolated complexes.

9. Accelerated lesion development in experimental syphilis.