| Literature DB >> 1303290 |
C Van Broeckhoven1, H Backhovens, M Cruts, G De Winter, M Bruyland, P Cras, J J Martin.
Abstract
Genetic linkage studies with chromosome 21 DNA markers and mutation analysis of the beta-amyloid protein precursor gene located in 21q21.3 have indicated that early-onset Alzheimer's disease (EOAD) is a heterogeneous disorder for which at least one other chromosomal locus exists. We examined two extended histopathologically confirmed EOAD pedigrees, AD/A and AD/B, with highly informative short tandem repeat (STR) polymorphisms and found complete linkage of the disease to a (CA)n dinucleotide repeat polymorphism at locus D14S43 in 14q24.3 (Zmax = 13.25 at theta = 0.0). Using additional chromosome 14 STR polymorphisms we were able to delineate the region containing the EOAD gene to an area of, at most, 8.9 centiMorgans between D14S42 and D14S53, flanking D14S43 on both sides.Entities:
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Year: 1992 PMID： 1303290 DOI： 10.1038/ng1292-335
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330